The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GBP  -  guanylate binding protein

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GBP

  • ChIFN-gamma from COS cells and E. coli both potently induced GBP RNA synthesis but were rather poor antiviral agents [1].
  • Recombinant DuIFN-gamma induces the transcription of several IFN-inducible genes including IFN regulatory factor 1 and guanylate-binding protein, and it exhibits antiviral activity that protects duck cells from vesicular stomatitis virus-mediated lysis [2].

High impact information on GBP

  • Low GBP RNA levels were found in cells treated with type I interferon, whereas very high levels were observed in cells treated with supernatant of a chicken T cell line that secretes a gamma-interferon-like activity [3].
  • Like mammalian GBPs, recombinant chicken GBP specifically bound to agarose-immobilized guanine nucleotides and hydrolyzed GTP to both GDP and GMP [3].
  • The other parts of chicken GBP are poorly conserved, except for a CAAX motif at the extreme C terminus which might signal isoprenylation [3].
  • To characterize the cytokine responsible for the GBP-inducing activity, we chose a cDNA expression cloning strategy in COS cells [1].
  • Supernatants of the chicken T cell line 855 contain antiviral and macrophage activating factor activity and strongly activate transcription of the guanylate binding protein (GBP) gene in chicken cells [1].

Anatomical context of GBP


  1. Biological properties of recombinant chicken interferon-gamma. Weining, K.C., Schultz, U., Münster, U., Kaspers, B., Staeheli, P. Eur. J. Immunol. (1996) [Pubmed]
  2. Recombinant duck interferon gamma inhibits duck hepatitis B virus replication in primary hepatocytes. Schultz, U., Chisari, F.V. J. Virol. (1999) [Pubmed]
  3. Chicken guanylate-binding protein. Conservation of GTPase activity and induction by cytokines. Schwemmle, M., Kaspers, B., Irion, A., Staeheli, P., Schultz, U. J. Biol. Chem. (1996) [Pubmed]
  4. Vaccinia virus-encoded cytokine receptor binds and neutralizes chicken interferon-gamma. Puehler, F., Weining, K.C., Symons, J.A., Smith, G.L., Staeheli, P. Virology (1998) [Pubmed]
WikiGenes - Universities