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Gene Review

HEYL  -  hes-related family bHLH transcription...

Homo sapiens

Synonyms: BHLHB33, Class B basic helix-loop-helix protein 33, HESR3, HEY3, HRT-3, ...
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Disease relevance of HEYL

  • In contrast to other tumor types, invasive breast cancer vasculature induced a high expression level of specific transcription factors, including SNAIL1 and HEYL, that may drive gene expression changes necessary for breast tumor neovascularization [1].
  • Post-inflammatory elastolysis and cutis laxa (Marshall, Heyl & Weber, 1966) is a skin disease in African infants which appears to be comparatively common in at least two countries [2].
  • Two of the murine isolates were identified as indole-negative variant strains of Pasteurella pneumotropica sensu stricto (i.e., type Jawetz), or of the type Heyl of Pasteurella pneumotropica, respectively [3].

High impact information on HEYL

  • We demonstrate the expression of HEYL in tumor endothelial cells and additionally establish the ability of HEYL to both induce proliferation and attenuate programmed cell death of primary endothelial cells in vitro [1].
  • We have isolated and characterized three new hairy-related bHLH transcription factor genes from mouse and human (hairy and Enhancer-of-split related with YRPW motif; HEY1, HEY2, and HEYL) [4].
  • Diwata (on Mindanao, Philippines), who were diagnosed to be mercury (Hg) intoxicated, were orally treated with 2 x 200 mg of the chelating agent DMPS (Dimaval, Co. Heyl, Germany) for 14 days in the course of a UNIDO project focusing on mercury pollution abatement [5].


  1. Alterations in vascular gene expression in invasive breast carcinoma. Parker, B.S., Argani, P., Cook, B.P., Liangfeng, H., Chartrand, S.D., Zhang, M., Saha, S., Bardelli, A., Jiang, Y., St Martin, T.B., Nacht, M., Teicher, B.A., Klinger, K.W., Sukumar, S., Madden, S.L. Cancer Res. (2004) [Pubmed]
  2. Post-inflammatory elastolysis and cutis laxa. Verhagen, A.R., Woerdeman, M.J. Br. J. Dermatol. (1975) [Pubmed]
  3. Lack of evidence for the occurrence of Pasteurella ureae in rodents. Mutters, R., Frederiksen, W., Mannheim, W. Vet. Microbiol. (1984) [Pubmed]
  4. Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. Steidl, C., Leimeister, C., Klamt, B., Maier, M., Nanda, I., Dixon, M., Clarke, R., Schmid, M., Gessler, M. Genomics (2000) [Pubmed]
  5. The Mt. Diwata study on the Philippines 2000-treatment of mercury intoxicated inhabitants of a gold mining area with DMPS (2,3-dimercapto-1-propane-sulfonic acid, Dimaval). Böse-O'Reilly, S., Drasch, G., Beinhoff, C., Maydl, S., Vosko, M.R., Roider, G., Dzaja, D. Sci. Total Environ. (2003) [Pubmed]
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