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Gene Review

Heyl  -  hairy/enhancer-of-split related with YRPW...

Mus musculus

Synonyms: HRT-3, Hairy and enhancer of split-related protein 3, Hairy-related transcription factor 3, Hairy/enhancer-of-split related with YRPW motif-like protein, Hesr3, ...
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Disease relevance of Heyl

  • Strains originally described as Pasteurella pneumotropica were reclassified as [Pasteurella] pneumotropica Heyl biotype (7), [P.] pneumotropica Jawetz biotype (1), Pasteurella dagmatis (1) or Taxon 22 (2) [1].

High impact information on Heyl

  • In the phylogeny, the isolates were clearly classified into three groups as follows: group A for the isolates of biotype Jawetz derived from mice, group B for the isolates of biotype Jawetz derived from rats, and group C for the isolates of biotype Heyl [2].
  • According to phenotypic reactions and 16S rDNA sequencing, the isolates were most similar to biotype Heyl [3].
  • Field isolates subjected to random amplified polymorphic DNA (RAPD) analysis had high genetic diversity among biotype Jawetz strains in contrast to biotype Heyl strains [4].

Analytical, diagnostic and therapeutic context of Heyl

  • Polymerase chain reaction (PCR) products were two distinctive fragments of 937 and 564 bp specific for biotypes Jawetz and Heyl, respectively [4].
  • The RAPD-PCR unambiguously differentiated Heyl and Jawetz biotypes of P. pneumotropica recovered from mice, identified two additional genetic groups for rat and hamster isolates, and clearly distinguished P. pneumotropica from related bacteria [5].
  • Heat inactivated whole cell preparations of an isolate of P. pneumotropica biotype Heyl (strain P 166) served as antigen for the ELISA procedure and for immune serum production in germ-free Han:NMRI mice [6].


  1. Reclassification of 30 Pasteurellaceae strains isolated from rodents. Boot, R., Bisgaard, M. Lab. Anim. (1995) [Pubmed]
  2. Phylogenetic Analysis of Isolates of Pasteurella pneumotropica from Laboratory Animals Based on the gyrB Gene Sequence. Hayashimoto, N., Ueno, M., Takakura, A., Itoh, T. Exp. Anim. (2006) [Pubmed]
  3. Outbreak of Pasteurella pneumotropica in a closed colony of STOCK-Cd28(tm1Mak) mice. Artwohl, J.E., Flynn, J.C., Bunte, R.M., Angen, O., Herold, K.C. Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science. (2000) [Pubmed]
  4. Identification by 16S rDNA fragment amplification and determination of genetic diversity by random amplified polymorphic DNA analysis of Pasteurella pneumotropica isolated from laboratory rodents. Kodjo, A., Villard, L., Veillet, F., Escande, F., Borges, E., Maurin, F., Bonnod, J., Richard, Y. Lab. Anim. Sci. (1999) [Pubmed]
  5. Randomly amplified polymorphic DNA polymerase chain reaction assay for molecular epidemiologic investigation of Pasteurella pneumotropica in laboratory rodent colonies. Weigler, B.J., Thigpen, J.E., Goelz, M.F., Babineau, C.A., Forsythe, D.B. Lab. Anim. Sci. (1996) [Pubmed]
  6. An enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to Pasteurella pneumotropica in murine colonies. Wullenweber-Schmidt, M., Meyer, B., Kraft, V., Kaspareit, J. Lab. Anim. Sci. (1988) [Pubmed]
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