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Gene Review:

ITGB1BP2 - integrin beta 1 binding protein (melusin) 2

Homo sapiens

Synonyms: CHORDC3, ITGB1BP, Integrin beta-1-binding protein 2, MELUSIN, MSTP015, ...

Brancaccio, M. et al.

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High impact information on ITGB1BP2

In vitro binding experiments demonstrated that interaction of full-length Melusin with detergent-solubilized integrin heterodimers occurred only in absence of cations, suggesting that it can be regulated by intracellular signals affecting Ca(2+) concentration [1].
Melusin is expressed in skeletal and cardiac muscles but not in smooth muscles or other tissues [1].

Associations of ITGB1BP2 with chemical compounds

Here we describe the isolation and partial characterization of a new muscle-specific protein (Melusin) which interacts with the integrin cytoplasmic domain [1].

Analytical, diagnostic and therapeutic context of ITGB1BP2

Immunofluorescence analysis showed that Melusin is present in a costamere-like pattern consisting of two rows flanking alpha-actinin at Z line [1].

References

Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. Brancaccio, M., Guazzone, S., Menini, N., Sibona, E., Hirsch, E., De Andrea, M., Rocchi, M., Altruda, F., Tarone, G., Silengo, L. J. Biol. Chem. (1999) [Pubmed]

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