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Gene Review

ACTN1  -  actinin, alpha 1

Homo sapiens

Synonyms: Alpha-actinin cytoskeletal isoform, Alpha-actinin-1, F-actin cross-linking protein, Non-muscle alpha-actinin-1
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Disease relevance of ACTN1


Psychiatry related information on ACTN1

  • To optimize the parameters of labeling protein with IIE, a systematic assessment of the effects of pH, reactant concentrations, and reaction time was made using purified cardiac actin and gizzard alpha-actinin [5].

High impact information on ACTN1


Chemical compound and disease context of ACTN1


Biological context of ACTN1


Anatomical context of ACTN1


Associations of ACTN1 with chemical compounds


Physical interactions of ACTN1


Co-localisations of ACTN1


Regulatory relationships of ACTN1


Other interactions of ACTN1


Analytical, diagnostic and therapeutic context of ACTN1


  1. Myotilin, the limb-girdle muscular dystrophy 1A (LGMD1A) protein, cross-links actin filaments and controls sarcomere assembly. Salmikangas, P., van der Ven, P.F., Lalowski, M., Taivainen, A., Zhao, F., Suila, H., Schröder, R., Lappalainen, P., Fürst, D.O., Carpén, O. Hum. Mol. Genet. (2003) [Pubmed]
  2. The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells. Nikolopoulos, S.N., Spengler, B.A., Kisselbach, K., Evans, A.E., Biedler, J.L., Ross, R.A. Oncogene (2000) [Pubmed]
  3. Direct interaction between alpha-actinin and hepatitis C virus NS5B. Lan, S., Wang, H., Jiang, H., Mao, H., Liu, X., Zhang, X., Hu, Y., Xiang, L., Yuan, Z. FEBS Lett. (2003) [Pubmed]
  4. Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin. Zhao, Z., Deocharan, B., Scherer, P.E., Ozelius, L.J., Putterman, C. J. Immunol. (2006) [Pubmed]
  5. Preparation and reactions of an iodinated imidoester reagent with actin and alpha-actinin. Bright, G.R., Spooner, B.S. Anal. Biochem. (1983) [Pubmed]
  6. Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments. Djinović-Carugo, K., Young, P., Gautel, M., Saraste, M. Cell (1999) [Pubmed]
  7. The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Koenig, M., Monaco, A.P., Kunkel, L.M. Cell (1988) [Pubmed]
  8. Stress fiber sarcomeres of fibroblasts are contractile. Kreis, T.E., Birchmeier, W. Cell (1980) [Pubmed]
  9. Alpha-actinin: immunofluorescent localization of a muscle structural protein in nonmuscle cells. Lazarides, E., Burridge, K. Cell (1975) [Pubmed]
  10. alpha-Actinin deficiency in thrombasthenia: possible identity of alpha-actinin and glycoprotein III. Gerrard, J.M., Schollmeyer, J.V., Phillips, D.R., White, J.G. Am. J. Pathol. (1979) [Pubmed]
  11. Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite. Planavila, A., Rodríguez-Calvo, R., de Arriba, A.F., Sánchez, R.M., Laguna, J.C., Merlos, M., Vazquez-Carrera, M. Mol. Pharmacol. (2006) [Pubmed]
  12. Alpha-actinin and myosin light chains in congenital nemaline myopathy. Wallgren-Pettersson, C., Arjomaa, P., Holmberg, C. Pediatric neurology. (1990) [Pubmed]
  13. Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome. Guan, N., Ding, J., Zhang, J., Yang, J. Pediatr. Nephrol. (2003) [Pubmed]
  14. Actin, tropomyosin and alpha-actinin as markers of differentiation in human rhabdomyosarcoma cell lines induced with dimethyl sulfoxide. Prados, J., Melguizo, C., Fernandez, J.E., Aranega, A.E., Alvarez, L., Aranega, A. Cell. Mol. Biol. (Noisy-le-grand) (1993) [Pubmed]
  15. Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells. Bauer, K., Kratzer, M., Otte, M., de Quintana, K.L., Hagmann, J., Arnold, G.J., Eckerskorn, C., Lottspeich, F., Siess, W. Blood (2000) [Pubmed]
  16. Analysis of the alpha-actinin/zyxin interaction. Li, B., Trueb, B. J. Biol. Chem. (2001) [Pubmed]
  17. Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network. Yürüker, B., Niggli, V. J. Cell. Sci. (1992) [Pubmed]
  18. Structural dynamics of alpha-actinin-vinculin interactions. Bois, P.R., Borgon, R.A., Vonrhein, C., Izard, T. Mol. Cell. Biol. (2005) [Pubmed]
  19. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. Burgueño, J., Blake, D.J., Benson, M.A., Tinsley, C.L., Esapa, C.T., Canela, E.I., Penela, P., Mallol, J., Mayor, F., Lluis, C., Franco, R., Ciruela, F. J. Biol. Chem. (2003) [Pubmed]
  20. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. Vallenius, T., Mäkelä, T.P. J. Cell. Sci. (2002) [Pubmed]
  21. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. Garvalov, B.K., Higgins, T.E., Sutherland, J.D., Zettl, M., Scaplehorn, N., Köcher, T., Piddini, E., Griffiths, G., Way, M. J. Cell Biol. (2003) [Pubmed]
  22. Pathological shear stress stimulates the tyrosine phosphorylation of alpha-actinin associated with the glycoprotein Ib-IX complex. Feng, S., Reséndiz, J.C., Christodoulides, N., Lu, X., Arboleda, D., Berndt, M.C., Kroll, M.H. Biochemistry (2002) [Pubmed]
  23. Phosphoinositide binding regulates alpha-actinin dynamics: mechanism for modulating cytoskeletal remodeling. Fraley, T.S., Pereira, C.B., Tran, T.C., Singleton, C., Greenwood, J.A. J. Biol. Chem. (2005) [Pubmed]
  24. The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. Izaguirre, G., Aguirre, L., Hu, Y.P., Lee, H.Y., Schlaepfer, D.D., Aneskievich, B.J., Haimovich, B. J. Biol. Chem. (2001) [Pubmed]
  25. Interaction of PKN with alpha-actinin. Mukai, H., Toshimori, M., Shibata, H., Takanaga, H., Kitagawa, M., Miyahara, M., Shimakawa, M., Ono, Y. J. Biol. Chem. (1997) [Pubmed]
  26. The lipoma preferred partner LPP interacts with alpha-actinin. Li, B., Zhuang, L., Reinhard, M., Trueb, B. J. Cell. Sci. (2003) [Pubmed]
  27. Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. Knudsen, K.A., Soler, A.P., Johnson, K.R., Wheelock, M.J. J. Cell Biol. (1995) [Pubmed]
  28. An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment. Reinhard, M., Zumbrunn, J., Jaquemar, D., Kuhn, M., Walter, U., Trueb, B. J. Biol. Chem. (1999) [Pubmed]
  29. Structure of the alpha-actinin-vinculin head domain complex determined by cryo-electron microscopy. Kelly, D.F., Taylor, D.W., Bakolitsa, C., Bobkov, A.A., Bankston, L., Liddington, R.C., Taylor, K.A. J. Mol. Biol. (2006) [Pubmed]
  30. Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2. Kotaka, M., Kostin, S., Ngai, S., Chan, K., Lau, Y., Lee, S.M., Li, H., Ng, E.K., Schaper, J., Tsui, S.K., Fung, K., Lee, C., Waye, M.M. J. Cell. Biochem. (2000) [Pubmed]
  31. Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function. Moncman, C.L., Wang, K. Exp. Cell Res. (2002) [Pubmed]
  32. Intermediate filament protein synemin is present in human reactive and malignant astrocytes and associates with ruffled membranes in astrocytoma cells. Jing, R., Pizzolato, G., Robson, R.M., Gabbiani, G., Skalli, O. Glia (2005) [Pubmed]
  33. Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. Park, J.B., Kim, J.H., Kim, Y., Ha, S.H., Yoo, J.S., Du, G., Frohman, M.A., Suh, P.G., Ryu, S.H. J. Biol. Chem. (2000) [Pubmed]
  34. Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4. Nuriya, M., Oh, S., Huganir, R.L. J. Neurochem. (2005) [Pubmed]
  35. Disruption of {alpha}-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis. Triplett, J.W., Pavalko, F.M. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  36. GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion. Shashidhar, S., Lorente, G., Nagavarapu, U., Nelson, A., Kuo, J., Cummins, J., Nikolich, K., Urfer, R., Foehr, E.D. Oncogene (2005) [Pubmed]
  37. von Willebrand factor binding to platelet glycoprotein Ib-IX-V stimulates the assembly of an alpha-actinin-based signaling complex. Reséndiz, J.C., Feng, S., Ji, G., Kroll, M.H. J. Thromb. Haemost. (2004) [Pubmed]
  38. A structural characterization of the interactions between titin Z-repeats and the alpha-actinin C-terminal domain. Joseph, C., Stier, G., O'Brien, R., Politou, A.S., Atkinson, R.A., Bianco, A., Ladbury, J.E., Martin, S.R., Pastore, A. Biochemistry (2001) [Pubmed]
  39. Plasma membrane Ca(2+)-ATPase associates with CLP36, alpha-actinin and actin in human platelets. Bozulic, L.D., Malik, M.T., Powell, D.W., Nanez, A., Link, A.J., Ramos, K.S., Dean, W.L. Thromb. Haemost. (2007) [Pubmed]
  40. Amorphin is phosphorylase; phosphorylase is an alpha-actinin-binding protein. Chowrashi, P., Mittal, B., Sanger, J.M., Sanger, J.W. Cell Motil. Cytoskeleton (2002) [Pubmed]
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