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Gene Review

Cul3  -  cullin 3

Mus musculus

Synonyms: AI467304, AW146203, CUL-3, Cullin-3, mKIAA0617
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High impact information on Cul3


Associations of Cul3 with chemical compounds

  • Together our data demonstrate that actinfilin acts as a scaffold, linking GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation [2].

Analytical, diagnostic and therapeutic context of Cul3


  1. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Cullinan, S.B., Gordan, J.D., Jin, J., Harper, J.W., Diehl, J.A. Mol. Cell. Biol. (2004) [Pubmed]
  2. Actinfilin Is a Cul3 Substrate Adaptor, Linking GluR6 Kainate Receptor Subunits to the Ubiquitin-Proteasome Pathway. Salinas, G.D., Blair, L.A., Needleman, L.A., Gonzales, J.D., Chen, Y., Li, M., Singer, J.D., Marshall, J. J. Biol. Chem. (2006) [Pubmed]
  3. Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis. Wang, S., Zheng, H., Esaki, Y., Kelly, F., Yan, W. Biol. Reprod. (2006) [Pubmed]
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