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Gene Review:

Cul3 - cullin 3

Mus musculus

Synonyms: AI467304, AW146203, CUL-3, Cullin-3, mKIAA0617

Salinas, G.D. et al., Wang, S. et al., Cullinan, S.B. et al.

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High impact information on Cul3

We demonstrate that Cul3-Keap1 complexes regulate Nrf2 polyubiquitination both in vitro and in vivo [1].
Actinfilin Is a Cul3 Substrate Adaptor, Linking GluR6 Kainate Receptor Subunits to the Ubiquitin-Proteasome Pathway [2].
In situ hybridization analysis localized Cul3 mRNA to spermatids in the adult testis [3].

Associations of Cul3 with chemical compounds

Together our data demonstrate that actinfilin acts as a scaffold, linking GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation [2].

Analytical, diagnostic and therapeutic context of Cul3

Northern blot and quantitative RT-PCR analyses demonstrated that Cul3 mRNA was preferentially expressed in the testis [3].

References

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Cullinan, S.B., Gordan, J.D., Jin, J., Harper, J.W., Diehl, J.A. Mol. Cell. Biol. (2004) [Pubmed]
Actinfilin Is a Cul3 Substrate Adaptor, Linking GluR6 Kainate Receptor Subunits to the Ubiquitin-Proteasome Pathway. Salinas, G.D., Blair, L.A., Needleman, L.A., Gonzales, J.D., Chen, Y., Li, M., Singer, J.D., Marshall, J. J. Biol. Chem. (2006) [Pubmed]
Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis. Wang, S., Zheng, H., Esaki, Y., Kelly, F., Yan, W. Biol. Reprod. (2006) [Pubmed]

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AgaP_AGAP008105	Anopheles gambiae str. PEST
CUL3	Bos taurus
cul-3	Caenorhabditis elegans
CUL3	Canis lupus familiaris
cul3b	Danio rerio
Cul3	Drosophila melanogaster
CUL3	Gallus gallus
CUL3	Homo sapiens
CUL3	Macaca mulatta
Os08g0170900	Oryza sativa Japonica Group
Os04g0643000	Oryza sativa Japonica Group
CUL3	Pan troglodytes
Cul3	Rattus norvegicus
cul3	Xenopus (Silurana) tropicalis

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