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Gene Review:

tnpA - transposase TnpA

Pseudomonas putida ND6

Han, C.G. et al., Hõrak, R. et al., Takizawa, N. et al., Brown, N.L. et al.

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Disease relevance of tnpA

The nucleotide sequence of the tnpA gene completes the sequence of the Pseudomonas transposon Tn501 [1].

High impact information on tnpA

IS679 has imperfect 25-bp terminal inverted repeats (IRs) and three open reading frames (ORFs) (here called tnpA, tnpB, and tnpC) [2].
The tnpA and tnpC products appear to have the amino acid sequence motif characteristic of most transposases [2].
In vivo experiments using transcriptional and translational fusions of the tnpA gene and the reporter gene gusA indicated that TnpC operates in the regulation of the transposase of Tn4652 at the post-transcriptional level [3].
Just downstream of the pah(PaK) gene cluster, a portion of a region was identical to one-third of the transposase gene (tnpA) in a phenol-catabolic plasmid pEST1226 [4].

References

The nucleotide sequence of the tnpA gene completes the sequence of the Pseudomonas transposon Tn501. Brown, N.L., Winnie, J.N., Fritzinger, D., Pridmore, R.D. Nucleic Acids Res. (1985) [Pubmed]
Structural and functional characterization of IS679 and IS66-family elements. Han, C.G., Shiga, Y., Tobe, T., Sasakawa, C., Ohtsubo, E. J. Bacteriol. (2001) [Pubmed]
Regulation of the transposase of Tn4652 by the transposon-encoded protein TnpC. Hõrak, R., Kivisaar, M. J. Bacteriol. (1999) [Pubmed]
Nucleotide sequences and characterization of genes encoding naphthalene upper pathway of pseudomonas aeruginosa PaK1 and Pseudomonas putida OUS82. Takizawa, N., Iida, T., Sawada, T., Yamauchi, K., Wang, Y.W., Fukuda, M., Kiyohara, H. J. Biosci. Bioeng. (1999) [Pubmed]

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