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Gene Review:

nahL - 2-oxopent-4-enoate hydratase

Pseudomonas putida ND6

Harayama, S. et al., Takenaka, S. et al.

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High impact information on nahL

The four 2-aminophenol-metabolizing enzymes, 2-aminomuconic 6-semialdehyde dehydrogenase, 2-aminomuconate deaminase, 4-oxalocrotonate decarboxylase, and 2-oxopent-4-enoate hydratase, were purified and characterized [1].
The gene order of the catabolic operon of NAH7 for salicylate oxidation was determined to be: promoter--nahG (the structural gene for salicylate hydroxylase)--nahH (catechol 2.3-dioxygenase)--nahI (hydroxymuconic semialdehyde dehydrogenase)--nahN (hydroxymuconic semialdehyde hydrolase)--nahL (2-oxopent-4-enoate hydratase) [2].

References

Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3. Takenaka, S., Murakami, S., Kim, Y.J., Aoki, K. Arch. Microbiol. (2000) [Pubmed]
Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids. Harayama, S., Rekik, M., Wasserfallen, A., Bairoch, A. Mol. Gen. Genet. (1987) [Pubmed]

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