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Gene Review:

tex - transcription accessory protein

Bordetella pertussis Tohama I

Fuchs, T.M. et al., He, X. et al.

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Disease relevance of tex

The new gene, termed tex, for toxin expression, seems to be an essential factor for B. pertussis, as it cannot be deleted from the bacterial chromosome [1].
Although tex in Streptococcus pneumoniae is homologous to that in B. pertussis, there are distinct differences [2].
The tex gene is named for its role in toxin expression in Bordetella pertussis, where it was characterized as an essential gene [2].

High impact information on tex

These sequence similarities and the fact that the tex gene was isolated by virtue of its effects on gene expression in B. pertussis indicate that the members of this new protein family may play an important role in the transcription machinery of prokaryotic organisms [1].
Since the tex gene in S. pneumoniae is not an essential gene, we were able to delete tex in strain D39 [2].

References

A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins. Fuchs, T.M., Deppisch, H., Scarlato, V., Gross, R. J. Bacteriol. (1996) [Pubmed]
Tex, a putative transcriptional accessory factor, is involved in pathogen fitness in Streptococcus pneumoniae. He, X., Thornton, J., Carmicle-Davis, S., McDaniel, L.S. Microb. Pathog. (2006) [Pubmed]

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