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Gene Review:

NPAS4 - neuronal PAS domain protein 4

Homo sapiens

Synonyms: BHLHE79, Class E basic helix-loop-helix protein 79, HLH-PAS transcription factor NXF, Le-PAS, NXF, ...

Ooe, N. et al., Shamloo, M. et al., Braun, I.C. et al.

Shamloo, Soriano, von Schack, Rickhag, Chin, Gonzalez-Zulueta, Gido, Urfer, Wieloch, Nikolich, Ooe, Saito, Mikami, Nakatuka, Kaneko,

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Disease relevance of NPAS4

Drebrin has been reported to be engaged in dendritic-cytoskeleton modulation at synapses, and such a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 in the mental retardation of Down's syndrome [1].
Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia [2].

High impact information on NPAS4

Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression [1].
Human TAP and its yeast orthologue Mex67p are members of the multigene family of NXF proteins [3].
We describe the identification and characterization of a recently cloned PAS domain protein termed Npas4 in ischemic rat brain [2].
Using gene expression profiling following middle cerebral artery occlusion, we showed that the Npas4 mRNA is differentially expressed in ischemic tissue [2].

References

Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Ooe, N., Saito, K., Mikami, N., Nakatuka, I., Kaneko, H. Mol. Cell. Biol. (2004) [Pubmed]
Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. Shamloo, M., Soriano, L., von Schack, D., Rickhag, M., Chin, D.J., Gonzalez-Zulueta, M., Gido, G., Urfer, R., Wieloch, T., Nikolich, K. Eur. J. Neurosci. (2006) [Pubmed]
Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. Braun, I.C., Herold, A., Rode, M., Conti, E., Izaurralde, E. J. Biol. Chem. (2001) [Pubmed]

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NPAS4	Bos taurus
NPAS4	Canis lupus familiaris
LOC100534657	Danio rerio
npas4a	Danio rerio
LOC101750093	Gallus gallus
NPAS4	Macaca mulatta
Npas4	Mus musculus
NPAS4	Pan troglodytes
Npas4	Rattus norvegicus
npas4	Xenopus (Silurana) tropicalis

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