Disease relevance of Rgr

• Human RGL4 was first identified in Jurkat cells in its truncated oncogenic form  [1].
• Oncogenic RGL4 is expressed in several T-Cell malignancies [1].
• Rgr was first identified as a fusion between the rabbit homolog of the Rad 23 gene and the Rgr gene in a rabbit squamous cell carcinoma [2].

High impact information on

• Because RAL is localized mainly to the Golgi, the expression of the RGR protein was identified in RK13 cells, a cell line that expresses endogenous rgr [3].
• Increasing amounts of expression result in enhanced localization of RGR to the plasma membrane [3].
• Biochemical and Biological Analyses of Rgr RalGEF Oncogene [Ref].
• The RalGDS-related (Rgr) oncogene belongs to the RalGDS family of guanine nucleotide exchange factors (GEFs) [2].

Anatomical context of Rgr

• The human form of the Rgr oncogene was identified in 2000, and expression of a mutant truncated transcript was detected in human T-cell malignancies and T-cell lines [1].

Associations of Rgr with chemical compounds

• Fluorescence in situ hybridization and Southern blot analyses revealed a homozygous deletion of an approximately 0.29-Mb genomic region bordered by the Rgr and DDT genes in these tumor cells [4].

References