Gene Review:
DDT - D-dopachrome tautomerase
Homo sapiens
Synonyms:
D-dopachrome decarboxylase, DDCT, Phenylpyruvate tautomerase II
Doerks,
Copley,
Bork,
Rwegoshora,
Sharpe,
Baisley,
Kittayapong,
Scippo,
Argiris,
Van De Weerdt,
Muller,
Willemsen,
Martial,
Maghuin-Rogister,
Eaton,
Gray,
Ostby,
Furr,
Wolf,
Lambright,
Parks,
Veeramachaneni,
Wilson,
Price,
Hotchkiss,
Orlando,
Guillette,
Nishihira,
Fujinaga,
Kuriyama,
Suzuki,
Sugimoto,
Nakagawa,
Tanaka,
Sakai,
- Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. Nishihira, J., Fujinaga, M., Kuriyama, T., Suzuki, M., Sugimoto, H., Nakagawa, A., Tanaka, I., Sakai, M. Biochem. Biophys. Res. Commun. (1998)
- Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Maness, S.C., McDonnell, D.P., Gaido, K.W. Toxicol. Appl. Pharmacol. (1998)
- Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: binding capability to the Ah receptor. Delescluse, C., Ledirac, N., de Sousa, G., Pralavorio, M., Lesca, P., Rahmani, R. Toxicol. Lett. (1998)
- Plasma organochlorine levels and the risk of breast cancer. Hunter, D.J., Hankinson, S.E., Laden, F., Colditz, G.A., Manson, J.E., Willett, W.C., Speizer, F.E., Wolff, M.S. N. Engl. J. Med. (1997)
- DDT-induced feminization of gull embryos. Fry, D.M., Toone, C.K. Science (1981)
- Cross-sectional study of a community with exceptional exposure to DDT. Kreiss, K., Zack, M.M., Kimbrough, R.D., Needham, L.L., Smrek, A.L., Jones, B.T. JAMA (1981)
- Development and characterization of molecularly imprinted sol-gel materials for the selective detection of DDT. Graham, A.L., Carlson, C.A., Edmiston, P.L. Anal. Chem. (2002)
- Toxicological and neuropsychological findings in patients presenting to an environmental toxicology service. Köppel, C., Fahron, G. J. Toxicol. Clin. Toxicol. (1995)
- Biting behavior and seasonal variation in the abundance of Anopheles minimus species A and C in Thailand. Rwegoshora, R.T., Sharpe, R.G., Baisley, K.J., Kittayapong, P. Southeast Asian J. Trop. Med. Public Health (2002)
- Some factors related to sum-DDT levels in Ugandan mothers' breast milk. Ejobi, F., Kanja, L.W., Kyule, M.N., Nyeko, J., Opuda-Asibo, J. Public health. (1998)
- Massachusetts Department of Public Health. Bats, rabies and DDT. Wells, L.F., Girard, K.F. N. Engl. J. Med. (1977)
- Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Kelce, W.R., Stone, C.R., Laws, S.C., Gray, L.E., Kemppainen, J.A., Wilson, E.M. Nature (1995)
- Unusual response of DDT-resistant houseflies to carbinol analogues of DDT. Sawicki, R.M. Nature (1978)
- Blood levels of organochlorine residues and risk of breast cancer. Wolff, M.S., Toniolo, P.G., Lee, E.W., Rivera, M., Dubin, N. J. Natl. Cancer Inst. (1993)
- DDT and related compounds and risk of pancreatic cancer. Garabrant, D.H., Held, J., Langholz, B., Peters, J.M., Mack, T.M. J. Natl. Cancer Inst. (1992)
- Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. Krieger, N., Wolff, M.S., Hiatt, R.A., Rivera, M., Vogelman, J., Orentreich, N. J. Natl. Cancer Inst. (1994)
- DDT mimicks estradiol stimulation of breast cancer cells to enter the cell cycle. Dees, C., Askari, M., Foster, J.S., Ahamed, S., Wimalasena, J. Mol. Carcinog. (1997)
- Irreversible binding and adrenocorticolytic activity of the DDT metabolite 3-methylsulfonyl-DDE examined in tissue-slice culture. Lindhe , O., Lund, B.O., Bergman , A., Brandt, I. Environ. Health Perspect. (2001)
- Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. Esumi, N., Budarf, M., Ciccarelli, L., Sellinger, B., Kozak, C.A., Wistow, G. Mamm. Genome (1998)
- Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole. Odh, G., Hindemith, A., Rosengren, A.M., Rosengren, E., Rorsman, H. Biochem. Biophys. Res. Commun. (1993)
- Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. Diel, P., Olff, S., Schmidt, S., Michna, H. J. Steroid Biochem. Mol. Biol. (2002)
- Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Sonneveld, E., Jansen, H.J., Riteco, J.A., Brouwer, A., van der Burg, B. Toxicol. Sci. (2005)
- DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells. Shen, K., Novak, R.F. Biochem. Biophys. Res. Commun. (1997)
- Effects of environmental antiandrogens on reproductive development in experimental animals. Gray, L.E., Ostby, J., Furr, J., Wolf, C.J., Lambright, C., Parks, L., Veeramachaneni, D.N., Wilson, V., Price, M., Hotchkiss, A., Orlando, E., Guillette, L. Hum. Reprod. Update (2001)
- Asymmetrical currents and sodium currents in Ranvier nodes exposed to DDT. Dubois, J.M., Bergman, C. Nature (1977)
- Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Danzo, B.J. Environ. Health Perspect. (1997)
- Antiandrogenic pesticides disrupt sexual characteristics in the adult male guppy Poecilia reticulata. Baatrup, E., Junge, M. Environ. Health Perspect. (2001)
- Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Gaido, K.W., Leonard, L.S., Lovell, S., Gould, J.C., Babaï, D., Portier, C.J., McDonnell, D.P. Toxicol. Appl. Pharmacol. (1997)
- Several environmental oestrogens are also anti-androgens. Sohoni, P., Sumpter, J.P. J. Endocrinol. (1998)
- Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells. Chen, C.W., Hurd, C., Vorojeikina, D.P., Arnold, S.F., Notides, A.C. Biochem. Pharmacol. (1997)
- Dietary estrogens stimulate human breast cells to enter the cell cycle. Dees, C., Foster, J.S., Ahamed, S., Wimalasena, J. Environ. Health Perspect. (1997)
- Biotransformation enzyme polymorphism and pesticide susceptibility. Eaton, D.L. Neurotoxicology (2000)
- CAR and PXR: xenosensors of endocrine disrupters? Kretschmer, X.C., Baldwin, W.S. Chem. Biol. Interact. (2005)
- Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Scippo, M.L., Argiris, C., Van De Weerdt, C., Muller, M., Willemsen, P., Martial, J., Maghuin-Rogister, G. Analytical and bioanalytical chemistry. (2004)
- Changes in enzyme titres with age in four geographical strains of Aedes aegypti and their association with insecticide resistance. Mourya, D.T., Hemingway, J., Leake, C.J. Med. Vet. Entomol. (1993)
- Differential regulation and xenobiotic induction of tandem P450 monooxygenase genes pc-1 (CYP63A1) and pc-2 (CYP63A2) in the white-rot fungus Phanerochaete chrysosporium. Doddapaneni, H., Yadav, J.S. Appl. Microbiol. Biotechnol. (2004)
- DDT -- a novel domain in different transcription and chromosome remodeling factors. Doerks, T., Copley, R., Bork, P. Trends Biochem. Sci. (2001)
- A case-control study of self-reported exposures to pesticides and pancreas cancer in southeastern Michigan. Fryzek, J.P., Garabrant, D.H., Harlow, S.D., Severson, R.K., Gillespie, B.W., Schenk, M., Schottenfeld, D. Int. J. Cancer (1997)
- Organochlorines and bone mineral density in Swedish men from the general population. Glynn, A.W., Michaëlsson, K., Lind, P.M., Wolk, A., Aune, M., Atuma, S., Darnerud, P.O., Mallmin, H. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2000)
- Exposure assessment for workers applying DDT to control malaria in Veracruz, Mexico. Rivero-Rodriguez, L., Borja-Aburto, V.H., Santos-Burgoa, C., Waliszewskiy, S., Rios, C., Cruz, V. Environ. Health Perspect. (1997)