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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HCA1  -  Hypercalciuria, absorptive, 1

Homo sapiens

Synonyms: AH, HCA
 
 
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Disease relevance of HCA1

 

High impact information on HCA1

  • As part of an attempt to elucidate the mechanism of NMF-induced radiosensitization, we examined the effects of NMF on chromatin structure, as reflected by changes in DNA-protein cross-links (DPCs) and the chromatin protein/DNA ratio, in two cell lines, clone A and HCA-1 [2].
  • The promoter of the HCA1 gene which is active in non-erythroid tissue shows strong sequence similarity with a similar region in the mouse CA1 gene, but has two equally used transcription start sites [3].
 

Analytical, diagnostic and therapeutic context of HCA1

  • LCR-E7 PCR was more sensitive than the HCA-1 test [4].

References

  1. Enhancement of radiation-induced DNA-protein crosslinking by N-methylformamide. Arundel, C.M., Tofilon, P.J. Radiat. Res. (1987) [Pubmed]
  2. Chromatin modifications associated with N-methylformamide-induced radiosensitization of clone A cells. Arundel, C.M., Vines, C.M., Tofilon, P.J. Cancer Res. (1988) [Pubmed]
  3. The human carbonic anhydrase I gene has two promoters with different tissue specificities. Brady, H.J., Lowe, N., Sowden, J.C., Edwards, M., Butterworth, P.H. Biochem. J. (1991) [Pubmed]
  4. A new PCR-based assay amplifies the E6-E7 genes of most mucosal human papillomaviruses (HPV). Sasagawa, T., Minemoto, Y., Basha, W., Yamazaki, H., Nakamura, M., Yoshimoto, H., Sakaike, J., Inoue, M. Virus Res. (2000) [Pubmed]
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