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Gene Review: 

Erc1  -  ELKS/RAB6-interacting/CAST family member 1

Rattus norvegicus

Synonyms: CAST, CAST2, CAZ-associated structural protein 2, Cast2, ELKS/Rab6-interacting/CAST family member 1, ...
 
 
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Disease relevance of Rab6ip2

 

High impact information on Rab6ip2

  • Alternative splicing of the C terminus of ERC1 generates a longer ERC1a variant that does not bind to RIMs and a shorter ERC1b variant that binds to RIMs, whereas the C terminus of ERC2 is synthesized only in a single RIM-binding variant [2].
  • These effects should be assessed in the clinical setting of ERCP and pancreas transplantation [3].
  • The clinical ERCP situation was imitated in groups (3) obstruction of the pancreatic duct and (4) infusion of contrast medium into the pancreatic duct plus obstruction [4].
 

Analytical, diagnostic and therapeutic context of Rab6ip2

References

  1. Effects of somatostatin and a long-acting somatostatin analogue on the prevention and treatment of experimentally induced acute pancreatitis in the rat. Baxter, J.N., Jenkins, S.A., Day, D.W., Roberts, N.B., Cowell, D.C., Mackie, C.R., Shields, R. The British journal of surgery. (1985) [Pubmed]
  2. A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Wang, Y., Liu, X., Biederer, T., Südhof, T.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Inosine reduces microcirculatory disturbance and inflammatory organ damage in experimental acute pancreatitis in rats. Schneider, L., Pietschmann, M., Hartwig, W., Marcos, S.S., Hackert, T., Gebhard, M.M., Uhl, W., Büchler, M.W., Werner, J. Am. J. Surg. (2006) [Pubmed]
  4. Effects of heparin in experimental models of acute pancreatitis and post-ERCP pancreatitis. Hackert, T., Werner, J., Gebhard, M.M., Klar, E. Surgery (2004) [Pubmed]
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