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Gene Review

ERC1  -  ELKS/RAB6-interacting/CAST family member 1

Homo sapiens

Synonyms: CAST2, Cast2, ELKS, ELKS/Rab6-interacting/CAST family member 1, ERC-1, ...
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Disease relevance of ERC1

  • The Louisville Behavioral Checklist was administered to 23 white boys between the ages of 7 and 12 years who completed treatment for Perthes disease by bracing or surgery at the Florida Elks Children's Hospital. The groups were comparable, with 11 children in the surgery group and 12 in the bracing group [1].
  • The performance of an ERCP 1 week after the admission for biliary pancreatitis will avoid a substantial number of unnecessary endoscopic sphincterotomies [2].

High impact information on ERC1

  • Here we report that liprin-alpha directly interacts with the ERC (ELKS-Rab6-interacting protein-CAST) family of proteins, members of which are known to bind RIMs, the active zone proteins that regulate neurotransmitter release [3].
  • Castration of sexually active doves reduces aromatase activity in preoptic and posterior hypothalamic areas (by greater than 75%) to basal levels, but does not affect the distribution or number of ERC in brain areas containing steroid-regulated aromatase activity, notably in the preoptic area [4].
  • We suggest that steroid-inducible aromatase activity and ERC are codistributed in areas controlling male sexual behavior; thus the formation and action of E may occur in the same area [4].
  • We examined whether (a) numbers of ERC and steroid-inducible aromatase activity are codistributed and directly correlated in the same brain areas of individual sexually active male doves and whether, (b) distribution of ERC is altered by a change in E formation in preoptic areas known to be involved in control of male behavior [4].
  • The presence of bile duct stones was recorded, as well as the time interval between admission and endoscopic retrograde cholangiopancreatography (ERCP) [2].

Associations of ERC1 with chemical compounds


  1. Behavioral sequelae of bracing versus surgery for Legg-Calvé-Perthes disease. Price, C.T., Day, D.D., Flynn, J.C. Journal of pediatric orthopedics. (1988) [Pubmed]
  2. Common bile duct stones in acute biliary pancreatitis: an endoscopic study. De Waele, B., Peterson, T., Smekens, L., Willems, G. Surgical laparoscopy & endoscopy. (1997) [Pubmed]
  3. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. Ko, J., Na, M., Kim, S., Lee, J.R., Kim, E. J. Biol. Chem. (2003) [Pubmed]
  4. Behavioral action of estrogen in the male dove brain: area differences in codistribution of aromatase activity and estrogen receptors are steroid-dependent. Gahr, M., Hutchison, J.B. Neuroendocrinology (1992) [Pubmed]
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