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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

NPSA  -  novel prostate-specific antigen

Homo sapiens

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Disease relevance of NPSA

  • Thus, the novel hNPSA, which has prostate-specific expression and seems to be involved in carcinogenesis, may have applications in the specific diagnosis and treatment of prostate cancer [1].

High impact information on NPSA

  • Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer [2].
  • The hNPSA (ORF) was subcloned into pET22b(+) vector and expressed using the histidine-tagged gene fusion system [1].
  • The hNPSA expression is upregulated 2.5- to 3-fold, both at the mRNA and protein levels in androgen-dependent LNCaP cells, as compared to normal whole prostate tissue [1].
  • CONCLUSIONS: The NPSA alert was effective and resulted in rapid development and implementation of local policies to reduce the availability of concentrated potassium chloride solutions [3].

Analytical, diagnostic and therapeutic context of NPSA

  • AVAILABILITY: The prediction is freely available over the Internet on the Network Protein Sequence Analysis (NPS@) WWW server at ml [4].
  • Analysis for tissue-specificity by Northern blot and RT-PCR-Southern blot procedures indicated that hNPSA is specifically expressed only in human prostate [1].


  1. Novel human prostate-specific cDNA: molecular cloning, expression, and immunobiology of the recombinant protein. Naz, R.K., Santhanam, R., Tyagi, N. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer. DiPaola, R.S., Rinehart, J., Nemunaitis, J., Ebbinghaus, S., Rubin, E., Capanna, T., Ciardella, M., Doyle-Lindrud, S., Goodwin, S., Fontaine, M., Adams, N., Williams, A., Schwartz, M., Winchell, G., Wickersham, K., Deutsch, P., Yao, S.L. J. Clin. Oncol. (2002) [Pubmed]
  3. Evaluation of the implementation of the alert issued by the UK National Patient Safety Agency on the storage and handling of potassium chloride concentrate solution. Lankshear, A.J., Sheldon, T.A., Lowson, K.V., Watt, I.S., Wright, J. Quality & safety in health care. (2005) [Pubmed]
  4. Improved performance in protein secondary structure prediction by inhomogeneous score combination. Guermeur, Y., Geourjon, C., Gallinari, P., Deléage, G. Bioinformatics (1999) [Pubmed]
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