The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

NPSA  -  novel prostate-specific antigen

Homo sapiens

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NPSA

  • Thus, the novel hNPSA, which has prostate-specific expression and seems to be involved in carcinogenesis, may have applications in the specific diagnosis and treatment of prostate cancer [1].
 

High impact information on NPSA

  • Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer [2].
  • The hNPSA (ORF) was subcloned into pET22b(+) vector and expressed using the histidine-tagged gene fusion system [1].
  • The hNPSA expression is upregulated 2.5- to 3-fold, both at the mRNA and protein levels in androgen-dependent LNCaP cells, as compared to normal whole prostate tissue [1].
  • CONCLUSIONS: The NPSA alert was effective and resulted in rapid development and implementation of local policies to reduce the availability of concentrated potassium chloride solutions [3].
 

Analytical, diagnostic and therapeutic context of NPSA

  • AVAILABILITY: The prediction is freely available over the Internet on the Network Protein Sequence Analysis (NPS@) WWW server at http://pbil.ibcp.fr/NPSA/npsa_server.ht ml [4].
  • Analysis for tissue-specificity by Northern blot and RT-PCR-Southern blot procedures indicated that hNPSA is specifically expressed only in human prostate [1].

References

  1. Novel human prostate-specific cDNA: molecular cloning, expression, and immunobiology of the recombinant protein. Naz, R.K., Santhanam, R., Tyagi, N. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer. DiPaola, R.S., Rinehart, J., Nemunaitis, J., Ebbinghaus, S., Rubin, E., Capanna, T., Ciardella, M., Doyle-Lindrud, S., Goodwin, S., Fontaine, M., Adams, N., Williams, A., Schwartz, M., Winchell, G., Wickersham, K., Deutsch, P., Yao, S.L. J. Clin. Oncol. (2002) [Pubmed]
  3. Evaluation of the implementation of the alert issued by the UK National Patient Safety Agency on the storage and handling of potassium chloride concentrate solution. Lankshear, A.J., Sheldon, T.A., Lowson, K.V., Watt, I.S., Wright, J. Quality & safety in health care. (2005) [Pubmed]
  4. Improved performance in protein secondary structure prediction by inhomogeneous score combination. Guermeur, Y., Geourjon, C., Gallinari, P., Deléage, G. Bioinformatics (1999) [Pubmed]
 
WikiGenes - Universities