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Gene Review:

rnh-2 - Protein RNH-2

Caenorhabditis elegans

Arudchandran, A. et al., Hannon, G.J. et al., Sandhu, S.K. et al.

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Disease relevance of rnh-2

The database searches also suggest that RNase H domains of LTR-retrotransposons in C. elegans are quite unrelated to cellular RNases H1, but numerous RNase H domains of human endogenous retroviruses are more closely related to cellular RNases H [1].

High impact information on rnh-2

We have used this cell-free system and oligodeoxynucleotide directed RNase H digestion to assess the U small nuclear RNA requirements for nematode cis- and trans-splicing [2].
Other interesting ESTs include systemic RNAi defective protein (sid-1), ribonuclease III family members (rnh-2 &rnc) and transposase gene (Tc3A) [3].

References

Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome. Arudchandran, A., Cerritelli, S.M., Bowen, N.J., Chen, X., Krause, M.W., Crouch, R.J. Mol. Biol. Evol. (2002) [Pubmed]
U small nuclear ribonucleoprotein requirements for nematode cis- and trans-splicing in vitro. Hannon, G.J., Maroney, P.A., Nilsen, T.W. J. Biol. Chem. (1991) [Pubmed]
Comparative analysis of the expressed genome of the infective juvenile entomopathogenic nematode, Heterorhabditis bacteriophora. Sandhu, S.K., Jagdale, G.B., Hogenhout, S.A., Grewal, P.S. Mol. Biochem. Parasitol. (2006) [Pubmed]

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AT2G25100	Arabidopsis thaliana
AGOS_AER363W	Ashbya gossypii ATCC 10895
RNASEH2A	Bos taurus
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Os11g0153900	Oryza sativa Japonica Group
RNASEH2A	Pan troglodytes
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RNH201	Saccharomyces cerevisiae S288c
rnh201	Schizosaccharomyces pombe 972h-
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