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Gene Review:

RPS6KC1 - ribosomal protein S6 kinase, 52kDa,...

Homo sapiens

Synonyms: 52 kDa ribosomal protein S6 kinase, RPK118, RSKL1, Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein, Ribosomal protein S6 kinase delta-1, ...

Liu, L. et al., Hayashi, S. et al., Zhang, H. et al.

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High impact information on RPS6KC1

RPK118 is also shown to co-localize with SPHK1 on early endosomes in COS7 cells expressing both recombinant proteins [1].
Furthermore, RPK118 specifically binds to phosphatidylinositol 3-phosphate [1].
Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1 [2].
Deletion studies showed that RPK118 interacted with PRDX3 through its pseudokinase domains, and with early endosomes through its PX domain [3].
Double immunofluorescence experiments demonstrated that PRDX3 co-localized with RPK118 on early endosomes in COS7 cells [3].

Associations of RPS6KC1 with chemical compounds

RPK118 is a sphingosine kinase-1-binding protein that has been implicated in sphingosine 1 phosphate-mediated signaling [3].

Other interactions of RPS6KC1

The pseudokinase 2 domain of RPK118 is responsible for SPHK1 binding as judged by yeast two-hybrid screening and immunoprecipitation studies [1].
In this study we identified a novel RPK118-binding protein, PRDX3 (peroxiredoxin-3), by yeast two-hybrid screening [3].

References

Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. Hayashi, S., Okada, T., Igarashi, N., Fujita, T., Jahangeer, S., Nakamura, S. J. Biol. Chem. (2002) [Pubmed]
Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1. Zhang, H., Yu, L., Mao, N., Fu, Q., Tu, Q., Gao, J., Zhao, S. Genomics (1999) [Pubmed]
RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Liu, L., Yang, C., Yuan, J., Chen, X., Xu, J., Wei, Y., Yang, J., Lin, G., Yu, L. Mol. Cells (2005) [Pubmed]

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