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Gene Review:

RNU105B - RNA, U105B small nucleolar

Homo sapiens

Synonyms: 105B, E1-2

Cao, K. et al., Roscoe, C.W. et al., Magenis, R.E. et al.

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Disease relevance of RNU105B

The data reported here also show that the neural MC3 receptor maps close to a disease locus for benign neonatal epilepsy in human and near the E1-2 epilepsy susceptibility locus in the mouse [1].

High impact information on RNU105B

Eighteen conjugates were synthesized by reaction of estrone-3,4-quinone (E1-3, 4-Q), estradiol-3,4-quinone (E2-3,4-Q), estrone-2,3-quinone (E1-2, 3-Q), or estradiol-2,3-quinone (E2-2,3-Q) with various sulfur nucleophiles, RSH, in which R is the cysteine, N-acetylcysteine, or glutathione moiety [2].
An organoboron carboxamido derivative of tetracycline, designed for use in the 105B-thermal neutron-capture treatment of cancer, was synthesized under the conditions of the Mannich reaction using perhydro-2-phenyl-1,3,6,2-dioxazaborocine as the amine component [3].

References

Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Magenis, R.E., Smith, L., Nadeau, J.H., Johnson, K.R., Mountjoy, K.G., Cone, R.D. Mamm. Genome (1994) [Pubmed]
Synthesis and structure elucidation of estrogen quinones conjugated with cysteine, N-acetylcysteine, and glutathione. Cao, K., Stack, D.E., Ramanathan, R., Gross, M.L., Rogan, E.G., Cavalieri, E.L. Chem. Res. Toxicol. (1998) [Pubmed]
New compounds: organoboron derivatives of tetracyclines I: synthesis of carboxamido derivative of tetracycline with perhydro-2-phenyl-1,3,6,2-dioxazaborocine. Roscoe, C.W., Phillips, J.W., Gillchriest, W.C. Journal of pharmaceutical sciences. (1977) [Pubmed]

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