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Gene Review:

SNORD80 - small nucleolar RNA, C/D box 80

Homo sapiens

Synonyms: RNU100, U80, Z15

Meyer, M. et al., Blad, H. et al., Langdon, N. et al.

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High impact information on SNORD80

The U6 RNA intramolecular stem-loop (ISL) is a conserved component of the spliceosome, and contains an essential metal ion binding site centered between a protonated adenine, A79, and U80 [1].
Comparison of glucose control using U80 and U100 strength insulin [2].
Diuresis increased in the Ularitide-treated groups and the placebo group after onset of infusion and did not show any significant difference in the first 12 h collection period (U0: 576, U5: 514, U20: 500, U40: 360, U80: 158 ML/12h (Median), (p = 0.16)) [3].

Analytical, diagnostic and therapeutic context of SNORD80

FINDINGS: The results indicate that Ularitide does not reduce the incidence of mechanical renal replacement therapy compared with placebo-treated patients during the first 12 h of treatment (U0: 36 (20), U5: 35 (11), U20: 36 (9), U40: 28 (8), U80: 41 (12), (% (n) (p = 0.87)) [3].

References

Dynamics and metal ion binding in the U6 RNA intramolecular stem-loop as analyzed by NMR. Blad, H., Reiter, N.J., Abildgaard, F., Markley, J.L., Butcher, S.E. J. Mol. Biol. (2005) [Pubmed]
Comparison of glucose control using U80 and U100 strength insulin. Langdon, N., Hyland, K., Yudkin, J.S. Diabet. Med. (1984) [Pubmed]
Therapeutic use of the natriuretic peptide ularitide in acute renal failure. Meyer, M., Pfarr, E., Schirmer, G., Uberbacher, H.J., Schöpe, K., Böhm, E., Flüge, T., Mentz, P., Scigalla, P., Forssmann, W.G. Renal failure. (1999) [Pubmed]

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