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Gene Review:

SNORD35A - small nucleolar RNA, C/D box 35A

Homo sapiens

Synonyms: RNU35, RNU35A, U35

Durant, P.C. et al., Cheng, H. et al., Skripkin, E. et al., Wirth, P.J. et al., Tomita, K. et al., et al.

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Disease relevance of SNORD35A

The Escherichia coli tRNA(Lys) modifications mnm(5)s(2)U34 and t(6)A37 have indeed been shown to remodel the anticodon loop, although significant dynamic flexibility remains within the weakly stacked U35 and U36 anticodon residues [1].
Through computational analysis, we infer homology between bacteriophage prohead proteases (MEROPS families U9 and U35) and herpesvirus protease (MEROPS family S21), and unify them into a procapsid protease superfamily [2].

High impact information on SNORD35A

Nucleotide sequencing of starfish mt tRNAAsn revealed that the anticodon is GPsiU, U35 at the anticodon second position being modified to pseudouridine (Psi) [3].
The crosslinked residues (nucleotide mcm5S2U34 and U35 in the anticodon loop of tRNA3(Lys) and UCU154 in the viral RNA upstream of the PBS) were mapped using a retardation method coupled with random hydrolysis [4].
Two additional polypeptides: U35, (27/6.05) and 58 (22/5.70) yielded N-terminal partial amino acid sequences but were not identified in established protein databases [5].
Large decreases in aminoacylation efficiency are observed upon mutagenesis of anticodon positions U35 and U36 of human tRNA(Lys,3) [6].

References

Structural effects of hypermodified nucleosides in the Escherichia coli and human tRNALys anticodon loop: the effect of nucleosides s2U, mcm5U, mcm5s2U, mnm5s2U, t6A, and ms2t6A. Durant, P.C., Bajji, A.C., Sundaram, M., Kumar, R.K., Davis, D.R. Biochemistry (2005) [Pubmed]
Double-stranded DNA bacteriophage prohead protease is homologous to herpesvirus protease. Cheng, H., Shen, N., Pei, J., Grishin, N.V. Protein Sci. (2004) [Pubmed]
The presence of pseudouridine in the anticodon alters the genetic code: a possible mechanism for assignment of the AAA lysine codon as asparagine in echinoderm mitochondria. Tomita, K., Ueda, T., Watanabe, K. Nucleic Acids Res. (1999) [Pubmed]
Psoralen crosslinking between human immunodeficiency virus type 1 RNA and primer tRNA3(Lys). Skripkin, E., Isel, C., Marquet, R., Ehresmann, B., Ehresmann, C. Nucleic Acids Res. (1996) [Pubmed]
Micropreparative immobilized pH gradient two-dimensional electrophoresis in combination with protein microsequencing for the analysis of human liver proteins. Wirth, P.J., Hoang, T.N., Benjamin, T. Electrophoresis (1995) [Pubmed]
Efficient aminoacylation of tRNA(Lys,3) by human lysyl-tRNA synthetase is dependent on covalent continuity between the acceptor stem and the anticodon domain. Stello, T., Hong, M., Musier-Forsyth, K. Nucleic Acids Res. (1999) [Pubmed]

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