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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Trpc7  -  transient receptor potential cation...

Mus musculus

Synonyms: Short transient receptor potential channel 7, TRP-7, TRP7, Transient receptor protein 7, Trp7, ...
 
 
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High impact information on Trpc7

  • Our findings suggest that hTRP7 is a store-operated calcium channel, a finding in stark contrast to the mouse orthologue, mTRP7, which is reported to enhance Ca(2+) influx independently of store depletion, and suggests that human and mouse TRP7 channels may fulfil different physiological roles [1].
  • TRP7 showed abundant RNA expression in the heart, lung, and eye and moderate expression in the brain, spleen, and testis [2].
  • PNI had no effect on TRP-7 action on astrocytes [3].
  • The anxiolytic action of the acute treatment with DZP was inhibited by the central administration of NKA and Trp-7 but not by SP [4].
 

Analytical, diagnostic and therapeutic context of Trpc7

  • This method identified five modified amino acids from five separate HPLC fractions: Trp7, Lys20, Arg29, Lys38, and Trp109 [5].

References

  1. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. Riccio, A., Mattei, C., Kelsell, R.E., Medhurst, A.D., Calver, A.R., Randall, A.D., Davis, J.B., Benham, C.D., Pangalos, M.N. J. Biol. Chem. (2002) [Pubmed]
  2. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. Okada, T., Inoue, R., Yamazaki, K., Maeda, A., Kurosaki, T., Yamakuni, T., Tanaka, I., Shimizu, S., Ikenaka, K., Imoto, K., Mori, Y. J. Biol. Chem. (1999) [Pubmed]
  3. Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture. Beecher, K.L., Andersen, T.T., Fenton, J.W., Festoff, B.W. J. Neurosci. Res. (1994) [Pubmed]
  4. Participation of GABAA receptors in the modulation of experimental anxiety by tachykinin agonists and antagonists in mice. Ribeiro, R.L., De Lima, T.C. Prog. Neuropsychopharmacol. Biol. Psychiatry (2002) [Pubmed]
  5. Direct photoaffinity labeling of cellular retinoic acid-binding protein I (CRABP-I) with all-trans-retinoic acid: identification of amino acids in the ligand binding site. Chen, G., Radominska-Pandya, A. Biochemistry (2000) [Pubmed]
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