Chemical Compound Review:
NEUROKININ A (3S)-3-[[(2S,3R)-2-[[(2S)-6- amino-2-[[(2S)...
Synonyms:
AC1NSKEQ, CHEMBL217406, CHEBI:311859, NKA
- Primary afferent tachykinins are required to experience moderate to intense pain. Cao, Y.Q., Mantyh, P.W., Carlson, E.J., Gillespie, A.M., Epstein, C.J., Basbaum, A.I. Nature (1998)
- Expression of substance P/neurokinin A-encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system. Sternini, C., Anderson, K., Frantz, G., Krause, J.E., Brecha, N. Gastroenterology (1989)
- Circulating markers of prognosis and response to treatment in patients with midgut carcinoid tumours. Turner, G.B., Johnston, B.T., McCance, D.R., McGinty, A., Watson, R.G., Patterson, C.C., Ardill, J.E. Gut (2006)
- Effects of nedocromil sodium on airway neurogenic mechanisms. Chung, K.F. J. Allergy Clin. Immunol. (1996)
- Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract. Maggi, C.A., Santicioli, P., Abelli, L., Parlani, M., Capasso, M., Conte, B., Giuliani, S., Meli, A. Naunyn Schmiedebergs Arch. Pharmacol. (1987)
- The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat. Fleetwood-Walker, S.M., Mitchell, R., Hope, P.J., El-Yassir, N., Molony, V., Bladon, C.M. Brain Res. (1990)
- Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. Theodorsson-Norheim, E., Jörnvall, H., Andersson, M., Norheim, I., Oberg, K., Jacobsson, G. Eur. J. Biochem. (1987)
- Neurokinin A and senktide attenuate scopolamine-induced impairment of spontaneous alternation performance in mice. Ukai, M., Shinkai, N., Kameyama, T. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. (1996)
- The tachykinin peptide family. Severini, C., Improta, G., Falconieri-Erspamer, G., Salvadori, S., Erspamer, V. Pharmacol. Rev. (2002)
- The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. Kawabata, A., Kinoshita, M., Nishikawa, H., Kuroda, R., Nishida, M., Araki, H., Arizono, N., Oda, Y., Kakehi, K. J. Clin. Invest. (2001)
- Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. Fox, A.J., Barnes, P.J., Venkatesan, P., Belvisi, M.G. J. Clin. Invest. (1997)
- Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. Fischer, A., McGregor, G.P., Saria, A., Philippin, B., Kummer, W. J. Clin. Invest. (1996)
- Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathways. Shapiro, M.S., Hille, B. Neuron (1993)
- Further evidence for the origin of circulating calcitonin gene-related peptide in the rat. Emson, P.C., Zaidi, M. J. Physiol. (Lond.) (1989)
- Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. Cao, W., Vrees, M.D., Potenti, F.M., Harnett, K.M., Fiocchi, C., Pricolo, V.E. J. Pharmacol. Exp. Ther. (2004)
- SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex. Yashpal, K., Hui-Chan, C.W., Henry, J.L. Eur. J. Pharmacol. (1996)
- Airway hyper-responsiveness to neurokinin A and bradykinin following Mycoplasma pneumoniae infection associated with reduced epithelial neutral endopeptidase. Tamaoki, J., Chiyotani, A., Tagaya, E., Araake, M., Nagai, A. Microbiology (Reading, Engl.) (1998)
- Independent coupling of the human tachykinin NK2 receptor to phospholipases C and A2 in transfected Chinese hamster ovary cells. Catalioto, R.M., Cucchi, P., Renzetti, A.R., Criscuoli, M., Maggi, C.A. Naunyn Schmiedebergs Arch. Pharmacol. (1998)
- Rectal distention-induced colonic net water secretion in rats involves tachykinins, capsaicin sensory, and vagus nerves. Eutamene, H., Theodorou, V., Fioramonti, J., Bueno, L. Gastroenterology (1997)
- gamma-Preprotachykinin-(72-92)-peptide amide: an endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors. Dam, T.V., Takeda, Y., Krause, J.E., Escher, E., Quirion, R. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P-induced salivation. Takeda, Y., Krause, J.E. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Calcitonin gene-related peptide stimulates proliferation of human endothelial cells. Haegerstrand, A., Dalsgaard, C.J., Jonzon, B., Larsson, O., Nilsson, J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. Krause, J.E., Chirgwin, J.M., Carter, M.S., Xu, Z.S., Hershey, A.D. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Neural emergency system in the stomach. Holzer, P. Gastroenterology (1998)
- Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A. Holzer, P., Guth, P.H. Circ. Res. (1991)
- Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma. Rameshwar, P., Gascón, P. Blood (1996)
- The troubled story of tachykinins and neurokinins. Maggi, C.A. Trends Pharmacol. Sci. (2000)
- Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. Markowitz, S., Saito, K., Moskowitz, M.A. J. Neurosci. (1987)
- The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor. Bhogal, N., Donnelly, D., Findlay, J.B. J. Biol. Chem. (1994)
- C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation. Alblas, J., van Etten, I., Khanum, A., Moolenaar, W.H. J. Biol. Chem. (1995)
- Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Liu, H., Cao, Y., Basbaum, A.I., Mazarati, A.M., Sankar, R., Wasterlain, C.G. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome". Jafri, F., El-Shewy, H.M., Lee, M.H., Kelly, M., Luttrell, D.K., Luttrell, L.M. J. Biol. Chem. (2006)
- Tachykinin and tachykinin receptor of an ascidian, Ciona intestinalis: evolutionary origin of the vertebrate tachykinin family. Satake, H., Ogasawara, M., Kawada, T., Masuda, K., Aoyama, M., Minakata, H., Chiba, T., Metoki, H., Satou, Y., Satoh, N. J. Biol. Chem. (2004)
- Pharmacological characterization of cloned human NK-2 (neurokinin A) receptor expressed in a baculovirus/Sf-21 insect cell system. Aharony, D., Little, J., Powell, S., Hopkins, B., Bundell, K.R., McPheat, W.L., Gordon, R.D., Hassall, G., Hockney, R., Griffin, R. Mol. Pharmacol. (1993)
- Tachykinin systems in the spinal cord and basal ganglia: influence of neonatal capsaicin treatment or dopaminergic intervention on levels of peptides, substance P-encoding mRNAs, and substance P receptor mRNA. Sivam, S.P., Krause, J.E. J. Neurochem. (1992)
- Desensitization to substance P-induced vasodilation in vitro is not shared by endogenous tachykinin neurokinin A. Moskowitz, M.A., Kuo, C., Leeman, S.E., Jessen, M.E., Derian, C.K. J. Neurosci. (1987)
- Neurokinin-A in bone and joint tissues: changes in adjuvant arthritis. Elhassan, A.M., Lindgren, J.U., Hultenby, K., Adem, A. J. Bone Miner. Res. (1999)