The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

NEUROKININ A     (3S)-3-[[(2S,3R)-2-[[(2S)-6- amino-2-[[(2S)...

Synonyms: AC1NSKEQ, CHEMBL217406, CHEBI:311859, NKA
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NEUROKININ A


Psychiatry related information on NEUROKININ A


High impact information on NEUROKININ A

  • Counterparts of skin tachykinins in mammalian tissues are SP, neurokinin A, and neurokinin B [9].
  • Intravenous calcitonin gene-related peptide (CGRP) and neurokinin A markedly elicited gastric mucus secretion, as did substance P to a lesser extent [10].
  • Electrically evoked nonadrenergic noncholinergic contractions of isolated bronchi mediated by the release of neurokinin A (NKA) from C-fibers, but not those elicited by exogenous NKA, were inhibited by NS1619 [11].
  • Substance P (SP), neurokinin A (NKA), and calcitonin gene-related peptide (CGRP) have potent proinflammatory effects in the airways [12].
  • Neurokinin A (1 microM) or B was without effect, implicating NK1 tachykinin receptors [13].

Chemical compound and disease context of NEUROKININ A

  • 2. Seven minutes following the intraperitoneal injection of capsaicin (10 mg/kg body weight) plasma CGRP and neurokinin A levels were found to rise by 15- and 4-fold respectively, while there was no change in circulating calcitonin levels [14].
  • In Fura 2-AM-loaded ulcerative colitis HSCM cells, neurokinin A- and caffeine-induced peak Ca(2+) increase and cell shortening were significantly reduced [15].
  • Finally, the hyperalgesia produced by sustained noxious thermal stimulation of the tip of the tail was unaffected by intrathecal administration of SR 48968; thus, it remains to find a physiological response in which endogenous neurokinin A and NK2 receptors at the spinal level are involved in the rat in vivo [16].
  • Airway hyper-responsiveness to neurokinin A and bradykinin following Mycoplasma pneumoniae infection associated with reduced epithelial neutral endopeptidase [17].
  • Pretreatment of the cells with pertussis toxin (500 ng/ml for 18 h) did not significantly modify the basal or stimulated phosphatidylinositol turnover but reduced the basal and NKA-induced PGE2 release by about 35% [18].

Biological context of NEUROKININ A


Anatomical context of NEUROKININ A


Associations of NEUROKININ A with other chemical compounds


Gene context of NEUROKININ A

  • These results indicate that the reduction of seizure activity and the neuroprotection observed in preprotachykinin A null mice are caused by the extinction of a SP/neurokinin A-mediated signaling pathway that is activated by seizures [31].
  • The NK1 receptor couples to both G(s) and G(q/11), resides on the plasma membrane, and mediates rapid ERK1/2 activation and nuclear translocation in response to neurokinin A [32].
  • The only Ci-TK receptor, Ci-TK-R, was equivalently activated by Ci-TK-I, SP, and neurokinin A at physiological concentrations, whereas Ci-TK-II showed 100-fold less potent activity, indicating that the ligand selectivity of Ci-TK-R is distinct from those of vertebrate TK receptors [33].
  • Pharmacological characterization of cloned human NK-2 (neurokinin A) receptor expressed in a baculovirus/Sf-21 insect cell system [34].
  • The spinal cord, striatum, or both were used for the quantification of tachykinin [SP and neurokinin A (NKA)] and opioid peptides [[Met5]-enkephalin (ME) and dynorphin A (1-8) (DYN)] by radioimmunoassays [35].

Analytical, diagnostic and therapeutic context of NEUROKININ A


  1. Primary afferent tachykinins are required to experience moderate to intense pain. Cao, Y.Q., Mantyh, P.W., Carlson, E.J., Gillespie, A.M., Epstein, C.J., Basbaum, A.I. Nature (1998) [Pubmed]
  2. Expression of substance P/neurokinin A-encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system. Sternini, C., Anderson, K., Frantz, G., Krause, J.E., Brecha, N. Gastroenterology (1989) [Pubmed]
  3. Circulating markers of prognosis and response to treatment in patients with midgut carcinoid tumours. Turner, G.B., Johnston, B.T., McCance, D.R., McGinty, A., Watson, R.G., Patterson, C.C., Ardill, J.E. Gut (2006) [Pubmed]
  4. Effects of nedocromil sodium on airway neurogenic mechanisms. Chung, K.F. J. Allergy Clin. Immunol. (1996) [Pubmed]
  5. Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract. Maggi, C.A., Santicioli, P., Abelli, L., Parlani, M., Capasso, M., Conte, B., Giuliani, S., Meli, A. Naunyn Schmiedebergs Arch. Pharmacol. (1987) [Pubmed]
  6. The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat. Fleetwood-Walker, S.M., Mitchell, R., Hope, P.J., El-Yassir, N., Molony, V., Bladon, C.M. Brain Res. (1990) [Pubmed]
  7. Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. Theodorsson-Norheim, E., Jörnvall, H., Andersson, M., Norheim, I., Oberg, K., Jacobsson, G. Eur. J. Biochem. (1987) [Pubmed]
  8. Neurokinin A and senktide attenuate scopolamine-induced impairment of spontaneous alternation performance in mice. Ukai, M., Shinkai, N., Kameyama, T. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. (1996) [Pubmed]
  9. The tachykinin peptide family. Severini, C., Improta, G., Falconieri-Erspamer, G., Salvadori, S., Erspamer, V. Pharmacol. Rev. (2002) [Pubmed]
  10. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. Kawabata, A., Kinoshita, M., Nishikawa, H., Kuroda, R., Nishida, M., Araki, H., Arizono, N., Oda, Y., Kakehi, K. J. Clin. Invest. (2001) [Pubmed]
  11. Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. Fox, A.J., Barnes, P.J., Venkatesan, P., Belvisi, M.G. J. Clin. Invest. (1997) [Pubmed]
  12. Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. Fischer, A., McGregor, G.P., Saria, A., Philippin, B., Kummer, W. J. Clin. Invest. (1996) [Pubmed]
  13. Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathways. Shapiro, M.S., Hille, B. Neuron (1993) [Pubmed]
  14. Further evidence for the origin of circulating calcitonin gene-related peptide in the rat. Emson, P.C., Zaidi, M. J. Physiol. (Lond.) (1989) [Pubmed]
  15. Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. Cao, W., Vrees, M.D., Potenti, F.M., Harnett, K.M., Fiocchi, C., Pricolo, V.E. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  16. SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex. Yashpal, K., Hui-Chan, C.W., Henry, J.L. Eur. J. Pharmacol. (1996) [Pubmed]
  17. Airway hyper-responsiveness to neurokinin A and bradykinin following Mycoplasma pneumoniae infection associated with reduced epithelial neutral endopeptidase. Tamaoki, J., Chiyotani, A., Tagaya, E., Araake, M., Nagai, A. Microbiology (Reading, Engl.) (1998) [Pubmed]
  18. Independent coupling of the human tachykinin NK2 receptor to phospholipases C and A2 in transfected Chinese hamster ovary cells. Catalioto, R.M., Cucchi, P., Renzetti, A.R., Criscuoli, M., Maggi, C.A. Naunyn Schmiedebergs Arch. Pharmacol. (1998) [Pubmed]
  19. Rectal distention-induced colonic net water secretion in rats involves tachykinins, capsaicin sensory, and vagus nerves. Eutamene, H., Theodorou, V., Fioramonti, J., Bueno, L. Gastroenterology (1997) [Pubmed]
  20. gamma-Preprotachykinin-(72-92)-peptide amide: an endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors. Dam, T.V., Takeda, Y., Krause, J.E., Escher, E., Quirion, R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  21. Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P-induced salivation. Takeda, Y., Krause, J.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  22. Calcitonin gene-related peptide stimulates proliferation of human endothelial cells. Haegerstrand, A., Dalsgaard, C.J., Jonzon, B., Larsson, O., Nilsson, J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  23. Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. Krause, J.E., Chirgwin, J.M., Carter, M.S., Xu, Z.S., Hershey, A.D. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  24. Neural emergency system in the stomach. Holzer, P. Gastroenterology (1998) [Pubmed]
  25. Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A. Holzer, P., Guth, P.H. Circ. Res. (1991) [Pubmed]
  26. Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma. Rameshwar, P., Gascón, P. Blood (1996) [Pubmed]
  27. The troubled story of tachykinins and neurokinins. Maggi, C.A. Trends Pharmacol. Sci. (2000) [Pubmed]
  28. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. Markowitz, S., Saito, K., Moskowitz, M.A. J. Neurosci. (1987) [Pubmed]
  29. The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor. Bhogal, N., Donnelly, D., Findlay, J.B. J. Biol. Chem. (1994) [Pubmed]
  30. C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation. Alblas, J., van Etten, I., Khanum, A., Moolenaar, W.H. J. Biol. Chem. (1995) [Pubmed]
  31. Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Liu, H., Cao, Y., Basbaum, A.I., Mazarati, A.M., Sankar, R., Wasterlain, C.G. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  32. Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome". Jafri, F., El-Shewy, H.M., Lee, M.H., Kelly, M., Luttrell, D.K., Luttrell, L.M. J. Biol. Chem. (2006) [Pubmed]
  33. Tachykinin and tachykinin receptor of an ascidian, Ciona intestinalis: evolutionary origin of the vertebrate tachykinin family. Satake, H., Ogasawara, M., Kawada, T., Masuda, K., Aoyama, M., Minakata, H., Chiba, T., Metoki, H., Satou, Y., Satoh, N. J. Biol. Chem. (2004) [Pubmed]
  34. Pharmacological characterization of cloned human NK-2 (neurokinin A) receptor expressed in a baculovirus/Sf-21 insect cell system. Aharony, D., Little, J., Powell, S., Hopkins, B., Bundell, K.R., McPheat, W.L., Gordon, R.D., Hassall, G., Hockney, R., Griffin, R. Mol. Pharmacol. (1993) [Pubmed]
  35. Tachykinin systems in the spinal cord and basal ganglia: influence of neonatal capsaicin treatment or dopaminergic intervention on levels of peptides, substance P-encoding mRNAs, and substance P receptor mRNA. Sivam, S.P., Krause, J.E. J. Neurochem. (1992) [Pubmed]
  36. Desensitization to substance P-induced vasodilation in vitro is not shared by endogenous tachykinin neurokinin A. Moskowitz, M.A., Kuo, C., Leeman, S.E., Jessen, M.E., Derian, C.K. J. Neurosci. (1987) [Pubmed]
  37. Neurokinin-A in bone and joint tissues: changes in adjuvant arthritis. Elhassan, A.M., Lindgren, J.U., Hultenby, K., Adem, A. J. Bone Miner. Res. (1999) [Pubmed]
WikiGenes - Universities