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Gene Review

UL49A  -  type 1 membrane protein; contains a signal...

Human herpesvirus 1

 
 
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Disease relevance of UL49A

  • Herpes simplex virus type 1 (HSV-1) gene UL49A potentially encodes a primary translation product of 91 residues with a signal sequence at the N terminus and a membrane anchor domain near the C terminus [1].
  • Characterization of the protein encoded by gene UL49A of herpes simplex virus type 1 [1].
  • The UL49A protein was efficiently solubilized along with envelope proteins by treatment of virions with a non-ionic detergent but only in the presence of a reducing agent, suggesting that it may be an envelope protein that is disulphide-linked to the tegument [1].
  • The EHV-4 gene corresponding to EHV-1 gene 10/VZV gene 9A/HSV-1 UL49A is of particular interest in that it is a newly identified herpesvirus gene whose product demonstrates features characteristic of membrane-inserted proteins [2].

References

 
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