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MeSH Review

Herpesvirus 4, Equid

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Disease relevance of Herpesvirus 4, Equid

  • Alignment of EHV-4 gB with HSV-1 (KOS) gB further revealed that four potential N-linked glycosylation sites and all 10 cysteine residues on the external surface of the molecules are perfectly conserved, suggesting that the proteins possess similar secondary and tertiary structures [1].
  • Hamsters were immunized with either an affinity-purified preparation of equid herpesvirus 1 (EHV-1) glycoprotein 13 (gp13) or synthetic peptides representing three sequences within the homologous glycoprotein of EHV-4, resulting in the production of anti-peptide (in the case of peptide-immunized animals) or antivirus antibodies [2].
  • The EHV-4 gH exhibits features previously reported to be conserved throughout the gH polypeptides of herpesviruses of all three subgroups [3].
  • Tracheal clearance rates (TCR) were determined before, during illness and following recovery in horses exposed to equine rhinovirus (ERhV-2), equine influenza virus (EIV) and equine herpesvirus (EHV-4) by means of lateral scintigraphs made following an injection of technetium-99m sulphide colloid into the tracheal lumen [4].

High impact information on Herpesvirus 4, Equid

  • A glycoprotein M-deleted equid herpesvirus 4 is severely impaired in virus egress and cell-to-cell spread [5].
  • A 24-amino-acid repeat sequence expressed as a glutathione S-transferase fusion protein specifically reacted as well as the type-specific region with sera from foals infected with EHV-4 [6].
  • We have determined the genomic location and nucleotide sequence of the equine herpesvirus 4 thymidine kinase (TK) gene [7].
  • The equine herpesvirus 4 (EHV-4) gene glycoprotein H (gH) gene homologue was localized by virtue of the conserved genomic position of this gene throughout members of the herpesvirus family [3].
  • Antibodies to these same three (EHV-4) or four (EHV-1) proteins, together with antibodies to the major capsid protein and proteins of 67K (EHV-4) and 87K (EHV-1) were detected in response to primary infection (control foal 2) and these sera had high neutralizating antibody titres [8].

Chemical compound and disease context of Herpesvirus 4, Equid


Biological context of Herpesvirus 4, Equid

  • In order to identify the role of the equine herpesvirus type 4 (EHV-4) glycoprotein I (gI) and E (gE) genes in determining viral virulence and their affect on the infection cycle, we constructed an EHV-4 recombinant strain containing a deletion in both gI and gE genes and its revertant [10].

Gene context of Herpesvirus 4, Equid


Analytical, diagnostic and therapeutic context of Herpesvirus 4, Equid


  1. Identification and nucleotide sequence of the glycoprotein gB gene of equine herpesvirus 4. Riggio, M.P., Cullinane, A.A., Onions, D.E. J. Virol. (1989) [Pubmed]
  2. Studies on glycoprotein 13 (gp13) of equid herpesvirus 1 using affinity-purified gp13, glycoprotein-specific monoclonal antibodies and synthetic peptides in a hamster model. Stokes, A., Corteyn, A.H., Pullen, L.A., Doel, T.R., Meredith, D.M., Killington, R.A., Halliburton, I.W., Whittaker, G.R., Wheldon, L.A., Nicolson, L. J. Gen. Virol. (1991) [Pubmed]
  3. The nucleotide sequence of an equine herpesvirus 4 gene homologue of the herpes simplex virus 1 glycoprotein H gene. Nicolson, L., Cullinane, A.A., Onions, D.E. J. Gen. Virol. (1990) [Pubmed]
  4. The effects of equine rhinovirus, influenza virus and herpesvirus infection on tracheal clearance rate in horses. Willoughby, R., Ecker, G., McKee, S., Riddolls, L., Vernaillen, C., Dubovi, E., Lein, D., Mahony, J.B., Chernesky, M., Nagy, E. Can. J. Vet. Res. (1992) [Pubmed]
  5. A glycoprotein M-deleted equid herpesvirus 4 is severely impaired in virus egress and cell-to-cell spread. Ziegler, C., Just, F.T., Lischewski, A., Elbers, K., Neubauer, A. J. Gen. Virol. (2005) [Pubmed]
  6. Development of an equine herpesvirus type 4-specific enzyme-linked immunosorbent assay using a B-cell epitope as an antigen. Maeda, K., Mizukoshi, F., Hamano, M., Kai, K., Iwata, H., Kondo, T., Matsumura, T. J. Clin. Microbiol. (2004) [Pubmed]
  7. The nucleotide sequence of the equine herpesvirus 4 thymidine kinase gene. Nicolson, L., Cullinane, A.A., Onions, D.E. J. Gen. Virol. (1990) [Pubmed]
  8. Comparative studies of the proteins of equine herpesviruses 4 and 1 and asinine herpesvirus 3: antibody response of the natural hosts. Crabb, B.S., Studdert, M.J. J. Gen. Virol. (1990) [Pubmed]
  9. Survival of equine herpesvirus-4, feline herpesvirus-1, and feline calicivirus in multidose ophthalmic solutions. Storey, E.S., Gerding, P.A., Scherba, G., Schaeffer, D.J. Veterinary ophthalmology. (2002) [Pubmed]
  10. A deletion in the gI and gE genes of equine herpesvirus type 4 reduces viral virulence in the natural host and affects virus transmission during cell-to-cell spread. Damiani, A.M., Matsumura, T., Yokoyama, N., Mikami, T., Takahashi, E. Virus Res. (2000) [Pubmed]
  11. Identification of the gB homologues of equine herpesvirus types 1 and 4 as disulphide-linked heterodimers and their characterization using monoclonal antibodies. Meredith, D.M., Stocks, J.M., Whittaker, G.R., Halliburton, I.W., Snowden, B.W., Killington, R.A. J. Gen. Virol. (1989) [Pubmed]
  12. gp13 (EHV-gC): a complement receptor induced by equine herpesviruses. Huemer, H.P., Nowotny, N., Crabb, B.S., Meyer, H., Hübert, P.H. Virus Res. (1995) [Pubmed]
  13. Detection and identification of equine herpesvirus-1 and -4 by polymerase chain reaction. Kirisawa, R., Endo, A., Iwai, H., Kawakami, Y. Vet. Microbiol. (1993) [Pubmed]
  14. Detection of equine herpesvirus and differentiation of equine herpesvirus type 1 from type 4 by the polymerase chain reaction. Wagner, W.N., Bogdan, J., Haines, D., Townsend, H.G., Misra, V. Can. J. Microbiol. (1992) [Pubmed]
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