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Gene Review

UL28  -  DNA packaging terminase subunit 2

Human herpesvirus 1

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Disease relevance of UL28

  • The UL28 protein of herpes simplex virus type 1 (HSV-1) is one of seven viral proteins required for the cleavage and packaging of viral DNA [1].
  • In order to define the functional domains of UL28 that are important for DNA cleavage/packaging, we constructed a series of HSV-1 mutants with linker insertion and nonsense mutations in UL28 [1].
  • An antiserum directed against a bacterial fusion protein containing UL28 protein sequences specifically recognized an 86,000 apparent Mr protein in immunoblots of wild-type capsids [2].
  • Amounts of UL28 protein were reduced in DNA-containing capsids and UL28 protein was not detected in virions, suggesting that some UL28 protein is lost during the cleavage-packaging reaction [2].

High impact information on UL28

  • Revertant viruses that formed plaques on Vero cells were detected for one of the lethal UL28 insertion mutants [1].
  • Previous results indicated that UL28 interacts with UL15 and UL33 to form a protein complex (terminase) that is presumed to cleave concatemeric DNA into genome lengths [1].


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