The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

UL28  -  DNA packaging terminase subunit 2

Human herpesvirus 1

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of UL28

  • The UL28 protein of herpes simplex virus type 1 (HSV-1) is one of seven viral proteins required for the cleavage and packaging of viral DNA [1].
  • In order to define the functional domains of UL28 that are important for DNA cleavage/packaging, we constructed a series of HSV-1 mutants with linker insertion and nonsense mutations in UL28 [1].
  • An antiserum directed against a bacterial fusion protein containing UL28 protein sequences specifically recognized an 86,000 apparent Mr protein in immunoblots of wild-type capsids [2].
  • Amounts of UL28 protein were reduced in DNA-containing capsids and UL28 protein was not detected in virions, suggesting that some UL28 protein is lost during the cleavage-packaging reaction [2].
 

High impact information on UL28

  • Revertant viruses that formed plaques on Vero cells were detected for one of the lethal UL28 insertion mutants [1].
  • Previous results indicated that UL28 interacts with UL15 and UL33 to form a protein complex (terminase) that is presumed to cleave concatemeric DNA into genome lengths [1].

References

 
WikiGenes - Universities