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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UL28  -  DNA packaging terminase subunit 2

Human herpesvirus 1

 
 
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Disease relevance of UL28

  • The UL28 protein of herpes simplex virus type 1 (HSV-1) is one of seven viral proteins required for the cleavage and packaging of viral DNA [1].
  • In order to define the functional domains of UL28 that are important for DNA cleavage/packaging, we constructed a series of HSV-1 mutants with linker insertion and nonsense mutations in UL28 [1].
  • An antiserum directed against a bacterial fusion protein containing UL28 protein sequences specifically recognized an 86,000 apparent Mr protein in immunoblots of wild-type capsids [2].
  • Amounts of UL28 protein were reduced in DNA-containing capsids and UL28 protein was not detected in virions, suggesting that some UL28 protein is lost during the cleavage-packaging reaction [2].
 

High impact information on UL28

  • Revertant viruses that formed plaques on Vero cells were detected for one of the lethal UL28 insertion mutants [1].
  • Previous results indicated that UL28 interacts with UL15 and UL33 to form a protein complex (terminase) that is presumed to cleave concatemeric DNA into genome lengths [1].

References

  1. Linker Insertion Mutations in the Herpes Simplex Virus Type 1 UL28 Gene: Effects on UL28 Interaction with UL15 and UL33 and Identification of a Second-Site Mutation in the UL15 Gene That Suppresses a Lethal UL28 Mutation. Jacobson, J.G., Yang, K., Baines, J.D., Homa, F.L. J. Virol. (2006) [Pubmed]
  2. Herpes simplex virus 1 DNA cleavage/packaging: the UL28 gene encodes a minor component of B capsids. Taus, N.S., Baines, J.D. Virology (1998) [Pubmed]
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