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Gene Review

Irf5  -  interferon regulatory factor 5

Mus musculus

Synonyms: AW491843, IRF-5, Interferon regulatory factor 5, mirf5
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High impact information on Irf5

  • Two members of the IFN regulatory factor (IRF) family of transcription factors, IRF-5 and IRF-7, interact with MyD88 and induce proinflammatory cytokines and type I IFNs, respectively [1].
  • Analysis of phosphorylation, nuclear translocation, dimerization, binding to CREB-binding protein, recognition of DNA, and induction of gene expression were used comparatively with IRF-3 as a measure of IRF-5 activation [2].
  • However, similar to the biological effects of IRF-3 activation, a constitutively active mutation of IRF-5 promoted apoptosis [2].
  • Consistently, Irf5-/- mice show resistance to lethal shock induced by either unmethylated DNA or lipopolysaccharide, which correlates with a marked decrease in the serum levels of proinflammatory cytokines [3].
  • Here, we demonstrate that the transcription factor IRF-5 is generally involved downstream of the TLR-MyD88 signalling pathway for gene induction of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-12 and tumour-necrosis factor-alpha [3].


  1. Negative regulation of Toll-like-receptor signaling by IRF-4. Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., Honda, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Differential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection. Cheng, T.F., Brzostek, S., Ando, O., Van Scoy, S., Kumar, K.P., Reich, N.C. J. Immunol. (2006) [Pubmed]
  3. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Takaoka, A., Yanai, H., Kondo, S., Duncan, G., Negishi, H., Mizutani, T., Kano, S., Honda, K., Ohba, Y., Mak, T.W., Taniguchi, T. Nature (2005) [Pubmed]
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