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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TSPAN13  -  tetraspanin 13

Homo sapiens

Synonyms: NET-6, NET6, TM4SF13, Tetraspan NET-6, Tetraspanin-13, ...
 
 
 
 
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Disease relevance of TSPAN13

 

High impact information on TSPAN13

  • In addition, NET-6 was markedly down-regulated in estrogen receptor-negative breast cancers, and expression was lowest in "basal-like" tumors [1].
  • NET-6 levels were lower in HER2-negative breast carcinoma cells [1].
  • The NET-6 gene was transfected into a low-expressing cell line, and the effect on cellular morphology, growth, and invasion in vitro was recorded [1].
  • The expression levels of NET-6 and TROP-2 were determined by quantitative reverse transcription-PCR in a subset of frozen tumors [1].
 

Other interactions of TSPAN13

  • NET-6 levels were decreased in estrogen receptor-negative and high-grade tumors, and ectopic expression of this gene had an inhibitory effect on proliferation and invasion [1].

References

  1. Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. Huang, H., Groth, J., Sossey-Alaoui, K., Hawthorn, L., Beall, S., Geradts, J. Clin. Cancer Res. (2005) [Pubmed]
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