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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FAM155B  -  family with sequence similarity 155, member B

Homo sapiens

Synonyms: CXorf63, Protein TED, TED, TMEM28, Transmembrane protein 28, ...
 
 
 
 
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Disease relevance of TMEM28

  • TED integration within the baculovirus genome thus represents one of the first examples of transposon-mediated transfer of host-derived genes to an eukaryotic virus [1].
  • TED is a lepidopteran retrotransposon found inserted within the DNA genome of the Autographa californica nuclear polyhedrosis virus mutant, FP-D [1].
  • These results indicated that TED ORFs 1 and 2 functionally resemble the retrovirus gag and pol genes and demonstrated for the first time that an invertebrate member of the gypsy family of elements encodes active forms of the structural and enzymatic functions necessary for transposition via an RNA intermediate [1].

References

  1. The baculovirus-integrated retrotransposon TED encodes gag and pol proteins that assemble into viruslike particles with reverse transcriptase. Lerch, R.A., Friesen, P.D. J. Virol. (1992) [Pubmed]
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