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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Nucleopolyhedrovirus

  • Purified budded virions of Autographa californica nuclear polyhedrosis virus (AcNPV) contain abundant amounts of free ubiquitin, which has an altered electrophoretic mobility on SDS gels as compared with standard ubiquitin [1].
  • We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter [2].
  • Apoptosis mediated by interleukin 1beta converting enzyme (ICE), which can be inhibited by Orgyia pseudotsugata nuclear polyhedrosis virus IAP (OpIAP) and cowpox virus crmA, was also inhibited by MIHA and MIHB [3].
  • To identify the protein responsible for the virion RNA polymerase activity, the complete 3.9 Kb DNA clone representing the largest RNA segment 1 (L1) of bluetongue virus (BTV-10) was placed under control of the polyhedrin promoter of Autographa californica nuclear polyhedrosis virus (AcNPV) [4].
  • An Autographa californica nuclear polyhedrosis virus gene encoding a 30-kilodalton polypeptide with two different sequence motifs characteristic of DNA-binding proteins was identified immediately downstream of the major capsid protein gene (vp39) [5].

High impact information on Nucleopolyhedrovirus


Chemical compound and disease context of Nucleopolyhedrovirus


Biological context of Nucleopolyhedrovirus


Anatomical context of Nucleopolyhedrovirus


Gene context of Nucleopolyhedrovirus


Analytical, diagnostic and therapeutic context of Nucleopolyhedrovirus


  1. Ubiquitin is attached to membranes of baculovirus particles by a novel type of phospholipid anchor. Guarino, L.A., Smith, G., Dong, W. Cell (1995) [Pubmed]
  2. Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line. Klaiber, K., Williams, N., Roberts, T.M., Papazian, D.M., Jan, L.Y., Miller, C. Neuron (1990) [Pubmed]
  3. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Uren, A.G., Pakusch, M., Hawkins, C.J., Puls, K.L., Vaux, D.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Expression of largest RNA segment and synthesis of VP1 protein of bluetongue virus in insect cells by recombinant baculovirus: association of VP1 protein with RNA polymerase activity. Urakawa, T., Ritter, D.G., Roy, P. Nucleic Acids Res. (1989) [Pubmed]
  5. A baculovirus gene with a novel transcription pattern encodes a polypeptide with a zinc finger and a leucine zipper. Thiem, S.M., Miller, L.K. J. Virol. (1989) [Pubmed]
  6. The promoter of the late p10 gene in the insect nuclear polyhedrosis virus Autographa californica: activation by viral gene products and sensitivity to DNA methylation. Knebel, D., Lübbert, H., Doerfler, W. EMBO J. (1985) [Pubmed]
  7. The structural protein ODV-EC27 of Autographa californica nucleopolyhedrovirus is a multifunctional viral cyclin. Belyavskyi, M., Braunagel, S.C., Summers, M.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. N-terminal sequences from Autographa californica nuclear polyhedrosis virus envelope proteins ODV-E66 and ODV-E25 are sufficient to direct reporter proteins to the nuclear envelope, intranuclear microvesicles and the envelope of occlusion derived virus. Hong, T., Summers, M.D., Braunagel, S.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Inhibition of interleukin 1 beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP. Hawkins, C.J., Uren, A.G., Häcker, G., Medcalf, R.L., Vaux, D.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Extension of Autographa californica nuclear polyhedrosis virus host range by interspecific replacement of a short DNA sequence in the p143 helicase gene. Croizier, G., Croizier, L., Argaud, O., Poudevigne, D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  11. A discrete stage of baculovirus GP64-mediated membrane fusion. Kingsley, D.H., Behbahani, A., Rashtian, A., Blissard, G.W., Zimmerberg, J. Mol. Biol. Cell (1999) [Pubmed]
  12. Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme. Brömme, D., Okamoto, K., Wang, B.B., Biroc, S. J. Biol. Chem. (1996) [Pubmed]
  13. The 35-kilodalton protein gene (p35) of Autographa californica nuclear polyhedrosis virus and the neomycin resistance gene provide dominant selection of recombinant baculoviruses. Lerch, R.A., Friesen, P.D. Nucleic Acids Res. (1993) [Pubmed]
  14. Specific binding of Autographa californica M nucleopolyhedrovirus occlusion-derived virus to midgut cells of Heliothis virescens larvae is mediated by products of pif genes Ac119 and Ac022 but not by Ac115. Ohkawa, T., Washburn, J.O., Sitapara, R., Sid, E., Volkman, L.E. J. Virol. (2005) [Pubmed]
  15. Properties of a baculovirus mutant defective in the protein phosphatase gene. Li, Y., Miller, L.K. J. Virol. (1995) [Pubmed]
  16. Cell-surface expression and purification of human CD4 produced in baculovirus-infected insect cells. Webb, N.R., Madoulet, C., Tosi, P.F., Broussard, D.R., Sneed, L., Nicolau, C., Summers, M.D. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. An unusual 30-kDa protein binding to the polyhedrin gene promoter of Autographa californica nuclear polyhedrosis virus. Burma, S., Mukherjee, B., Jain, A., Habib, S., Hasnain, S.E. J. Biol. Chem. (1994) [Pubmed]
  18. Phenotypic and genetic analysis of Lymantria dispar nucleopolyhedrovirus few polyhedra mutants: mutations in the 25K FP gene may be caused by DNA replication errors. Bischoff, D.S., Slavicek, J.M. J. Virol. (1997) [Pubmed]
  19. Expression of polyomavirus large T antigen by using a baculovirus vector. Rice, W.C., Lorimer, H.E., Prives, C., Miller, L.K. J. Virol. (1987) [Pubmed]
  20. Baculovirus gp64 gene expression: analysis of sequences modulating early transcription and transactivation by IE1. Blissard, G.W., Rohrmann, G.F. J. Virol. (1991) [Pubmed]
  21. Lymantria dispar nucleopolyhedrovirus hrf-1 expands the larval host range of Autographa californica nucleopolyhedrovirus. Chen, C.J., Quentin, M.E., Brennan, L.A., Kukel, C., Thiem, S.M. J. Virol. (1998) [Pubmed]
  22. Dual mutations in the Autographa californica nucleopolyhedrovirus FP-25 and p35 genes result in plasma-membrane blebbing in Trichoplusia ni cells. Kelly, B.J., King, L.A., Possee, R.D., Chapple, S.D. J. Gen. Virol. (2006) [Pubmed]
  23. A mutational analysis of the baculovirus inhibitor of apoptosis Op-IAP. Vucic, D., Kaiser, W.J., Miller, L.K. J. Biol. Chem. (1998) [Pubmed]
  24. Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat. Jones, M.L., Mulligan, M.S., Flory, C.M., Ward, P.A., Warren, J.S. J. Immunol. (1992) [Pubmed]
  25. Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. Ginns, E.I., Rehavi, M., Martin, B.M., Weller, M., O'Malley, K.L., LaMarca, M.E., McAllister, C.G., Paul, S.M. J. Biol. Chem. (1988) [Pubmed]
  26. The p95 gene of Bombyx mori nuclear polyhedrosis virus: temporal expression and functional properties. Lu, M., Swevers, L., Iatrou, K. J. Virol. (1998) [Pubmed]
  27. Identification of Epstein-Barr virus terminal protein 1 (TP1) in extracts of four lymphoid cell lines, expression in insect cells, and detection of antibodies in human sera. Frech, B., Zimber-Strobl, U., Suentzenich, K.O., Pavlish, O., Lenoir, G.M., Bornkamm, G.W., Mueller-Lantzsch, N. J. Virol. (1990) [Pubmed]
  28. In vivo and in vitro analysis of baculovirus ie-2 mutants. Prikhod'ko, E.A., Lu, A., Wilson, J.A., Miller, L.K. J. Virol. (1999) [Pubmed]
  29. Identification, localization, transcription, and sequence analysis of the Choristoneura fumiferana nuclear polyhedrosis virus DNA polymerase gene. Liu, J.J., Carstens, E.B. Virology (1995) [Pubmed]
  30. Restriction mapping of Lymantria dispar nuclear polyhedrosis virus DNA: localization of the polyhedrin gene and identification of four homologous regions. McClintock, J.T., Dougherty, E.M. J. Gen. Virol. (1988) [Pubmed]
  31. Potent virucidal activity in larval Heliothis virescens plasma against Helicoverpa zea single capsid nucleopolyhedrovirus. Popham, H.J., Shelby, K.S., Brandt, S.L., Coudron, T.A. J. Gen. Virol. (2004) [Pubmed]
  32. Molecular cloning and sequence analysis of the Anticarsia gemmatalis multicapsid nuclear polyhedrosis virus GP64 glycoprotein. Pilloff, M.G., Bilen, M.F., Belaich, M.N., Lozano, M.E., Ghiringhelli, P.D. Virus Genes (2003) [Pubmed]
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