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Gene Review:

KLHL20 - kelch-like family member 20

Homo sapiens

Synonyms: KHLHX, KLEIP, KLHLX, Kelch-like ECT2-interacting protein, Kelch-like protein 20, ...

Hara, T. et al.

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High impact information on KLHL20

KLEIP recruitment and actin assembly were induced around E-cadherin-coated beads placed on cell surfaces [1].
These observations strongly suggest that KLEIP is localized on actin filaments at the contact sites [1].
Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells [1].
We isolated a human kelch-related protein, Kelch-like ECT2 interacting protein (KLEIP), which contains the broad-complex, tramtrack, bric-a-brac (BTB)/poxvirus, zinc finger (POZ) motif and six-tandem kelch repeats [1].

Other interactions of KLHL20

The actin depolymerizing agent cytochalasin B inhibited this KLEIP recruitment around E-cadherin-coated beads [1].

References

Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. Hara, T., Ishida, H., Raziuddin, R., Dorkhom, S., Kamijo, K., Miki, T. Mol. Biol. Cell (2004) [Pubmed]

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KLHDB_ANOGA	Anopheles gambiae str. PEST
KLHL20	Bos taurus
R12E2.1	Caenorhabditis elegans
KLHL20	Canis lupus familiaris
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dbo	Drosophila melanogaster
KLHL20	Gallus gallus
Klhl20	Mus musculus
KLHL20	Pan troglodytes
Klhl20	Rattus norvegicus

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