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Gene Review

KLHL1  -  kelch-like family member 1

Homo sapiens

Synonyms: FLJ30047, KIAA1490, Kelch-like protein 1, MRP2
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Disease relevance of KLHL1

  • We found that klhl was a member of the kelch-repeat superfamily, containing two evolutionary conserved domains--broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domain, and kelch motif [1].
  • Despite the multiplicity of kelch-like proteins in orthopoxviruses, their function is still vague [2].
  • Effects of deletions of kelch-like genes on cowpox virus biological properties [3].

High impact information on KLHL1


Biological context of KLHL1


Anatomical context of KLHL1


Other interactions of KLHL1


Analytical, diagnostic and therapeutic context of KLHL1

  • Similarly, co-immunoprecipitation experiments in HEK cells and brain tissue exposed the presence of KLHL1 in protein samples immunoprecipitated with FLAG-tagged or alpha(1A) antibodies [9].


  1. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. Wu, Y.L., Gong, Z. Gene (2004) [Pubmed]
  2. Species-specific differences in organization of orthopoxvirus kelch-like proteins. Shchelkunov, S., Totmenin, A., Kolosova, I. Virus Genes (2002) [Pubmed]
  3. Effects of deletions of kelch-like genes on cowpox virus biological properties. Kochneva, G., Kolosova, I., Maksyutova, T., Ryabchikova, E., Shchelkunov, S. Arch. Virol. (2005) [Pubmed]
  4. KLHL1/MRP2 Mediates Neurite Outgrowth in a Glycogen Synthase Kinase 3{beta}-Dependent Manner. Seng, S., Avraham, H.K., Jiang, S., Venkatesh, S., Avraham, S. Mol. Cell. Biol. (2006) [Pubmed]
  5. The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). Nemes, J.P., Benzow, K.A., Moseley, M.L., Ranum, L.P., Koob, M.D. Hum. Mol. Genet. (2000) [Pubmed]
  6. Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. Hara, T., Ishida, H., Raziuddin, R., Dorkhom, S., Kamijo, K., Miki, T. Mol. Biol. Cell (2004) [Pubmed]
  7. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. Wolff, T., O'Neill, R.E., Palese, P. J. Virol. (1998) [Pubmed]
  8. The KLHL1-antisense transcript ( KLHL1AS) is evolutionarily conserved. Benzow, K.A., Koob, M.D. Mamm. Genome (2002) [Pubmed]
  9. The Kelch-like protein 1 modulates P/Q-type calcium current density. Aromolaran, K.A., Benzow, K.A., Koob, M.D., Piedras-Rentería, E.S. Neuroscience (2007) [Pubmed]
  10. Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis. Hinoi, E., Takarada, T., Fujimori, S., Wang, L., Iemata, M., Uno, K., Yoneda, Y. Bone (2007) [Pubmed]
  11. Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. Gupta-Rossi, N., Storck, S., Griebel, P.J., Reynaud, C.A., Weill, J.C., Dahan, A. Mol. Immunol. (2003) [Pubmed]
  12. Identification and characterization of a novel kelch-like gene KLHL15 in silico. Yoshida, K. Oncol. Rep. (2005) [Pubmed]
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