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Gene Review:

HTATSF1 - HIV-1 Tat specific factor 1

Homo sapiens

Synonyms: HIV Tat-specific factor 1, TAT-SF1, TATSF1, Tat-SF1, dJ196E23.2

Sudbrak, R. et al., Fong, Y.W. et al.

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Disease relevance of HTATSF1

The spliceosomal U small nuclear ribonucleoproteins (snRNPs) interact with human transcription elongation factor TAT-SF1 (refs 6,7,8,9) and strongly stimulate polymerase elongation when directed to an intron-free human immunodeficiency virus-1 (HIV-1) template [1].

High impact information on HTATSF1

It is concluded that this particular genomic organization of the extended class II region-i.e., the absence of class I genes and the presence of the HTATSF1-like and ZNF-like pseudogenes-can be traced back to a common ancestor of humans and rhesus macaques about 23 million years ago [2].

References

Stimulatory effect of splicing factors on transcriptional elongation. Fong, Y.W., Zhou, Q. Nature (2001) [Pubmed]
Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region. Sudbrak, R., Reinhardt, R., Hennig, S., Lehrach, H., Günther, E., Walter, L. Immunogenetics (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

HTATSF1	Bos taurus
HTATSF1	Canis lupus familiaris
htatsf1	Danio rerio
HTATSF1	Gallus gallus
HTATSF1	Macaca mulatta
Htatsf1	Mus musculus
HTATSF1	Pan troglodytes
Htatsf1	Rattus norvegicus
htatsf1	Xenopus (Silurana) tropicalis

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