Disease relevance of prtB

• Immediately downstream from the previously isolated Treponema denticola ATCC 35405 prtB gene coding for a chymotrypsinlike protease activity, an open reading frame, ORF3, was identified which shared significant homology with the highly conserved domains (HCDs) of bacterial methyl-accepting chemotaxis proteins (MCPs) [1].

High impact information on prtB

• Northern blot analysis suggested that dmcB was part of an operon structure containing prtB [1].
• Two potential inverted repeat sequences are present both upstream and downstream from the prtB gene [2].
• The genes flgE, tdpA, and prtB encoding the flagellar hook protein, a 53-kDa immunogenic protein, and chymotrypsinlike protease, respectively, were located on the map [3].

Biological context of prtB

• Nucleotide sequencing of the insert identified an open reading frame, designated the prtB gene, which codes for the protease [2].

References