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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Abcc5  -  ATP-binding cassette, sub-family C...

Mus musculus

Synonyms: 2900011L11Rik, AI132311, ATP-binding cassette sub-family C member 5, Abcc5a, Abcc5b, ...
 
 
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High impact information on Abcc5

  • In addition, Mrp1(-/-) astrocytes had a 50% higher specific GSH content than wild-type or Mrp5(-/-) cells [1].
  • Therefore, Mrp4 and Mrp5 may contribute to the efflux transport of E(2)17betaG and DNP-SG from the CSF [2].
 

Anatomical context of Abcc5

  • Investigation of individual cortical astrocytes and Bergmann glial cells revealed that these cells express Mrp1, Mrp4 and Mrp5 and that individual astrocytes can contain mRNA of one, two or three of these Mrps simultaneously [3].

References

  1. The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. Minich, T., Riemer, J., Schulz, J.B., Wielinga, P., Wijnholds, J., Dringen, R. J. Neurochem. (2006) [Pubmed]
  2. Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier? Lee, Y.J., Kusuhara, H., Sugiyama, Y. Journal of pharmaceutical sciences. (2004) [Pubmed]
  3. Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study. Hirrlinger, J., Moeller, H., Kirchhoff, F., Dringen, R. Neurochem. Res. (2005) [Pubmed]
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