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Gene Review

Abcc5  -  ATP-binding cassette, subfamily C...

Rattus norvegicus

Synonyms: ATP-binding cassette sub-family C member 5, Abcc5a, Mrp5, Multidrug resistance-associated protein 5
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Psychiatry related information on Abcc5


High impact information on Abcc5

  • At 10-13 weeks of age, MS15 rats had a lower ethanol intake whereas, the MS360 rats consumed more 8% ethanol solution compared with MS15 and animal facility-reared rats [2].
  • Ethanol-induced changes were observed in D(2)-like receptor density in the ventral tegmental area in MS360, and in the ventral tegmental area and frontal-parietal cortex in animal facility-reared rats [2].
  • The mRNA levels of Mrp5 and 3 were 10.6 and 7.60% of that of Mrp1, respectively [3].
  • In the hippocampus, mRNA expression of NMDA NR2B and AMPA GluR1 and GluR2 receptors was significantly lower in MS360 rats relative to MS15 [4].
  • Male Wistar rats were either separated from their mother for 15 min (MS15 or 'handling') or 360 min (MS360) once a day from pnd 1-21 and glutamate receptor expression levels were measured at 25 weeks of age using real-time RT-PCR analysis [4].

Biological context of Abcc5

  • Induction of pericentral Mrp3 and up-regulation of Mrp5 mRNA may play an important role in the hepatocellular clearance of cholephilic substances and cyclic nucleotides accumulating after LPS treatment [5].

Anatomical context of Abcc5

  • In stunned groups, the concentrations were 224.8 +/- 11.8 (MS15) and 241.7 +/- 6.0 (MS20) micrograms/g myocardium, decreased from those in ischemic groups but still higher than those in control group by 35.4 and 45.6%, respectively [6].
  • MS360 induced alterations in medial prefrontal cortex (MEAP) and amygdala (N/OFQ) [7].

Associations of Abcc5 with chemical compounds

  • In response to a restraint stress, MS360 rats had a blunted corticosterone release in contrast to MS15 and AFR rats [1].

Other interactions of Abcc5


Analytical, diagnostic and therapeutic context of Abcc5

  • In adult rat brain as well as in neural cell cultures the mRNAs coding for Mrp1, Mrp3, Mrp4 and Mrp5 were detected [8].


  1. Behavioral profiles and stress-induced corticosteroid secretion in male Wistar rats subjected to short and prolonged periods of maternal separation. Roman, E., Gustafsson, L., Berg, M., Nylander, I. Hormones and behavior (2006) [Pubmed]
  2. Long-term effects of maternal separation on ethanol intake and brain opioid and dopamine receptors in male Wistar rats. Ploj, K., Roman, E., Nylander, I. Neuroscience (2003) [Pubmed]
  3. Establishing a Method to Isolate Rat Brain Capillary Endothelial Cells by Magnetic Cell Sorting and Dominant mRNA Expression of Multidrug Resistance-associated Protein 1 and 4 in Highly Purified Rat Brain Capillary Endothelial Cells. Ohtsuki, S., Yamaguchi, H., Asashima, T., Terasaki, T. Pharm. Res. (2007) [Pubmed]
  4. Repeated maternal separation of male Wistar rats alters glutamate receptor expression in the hippocampus but not the prefrontal cortex. Pickering, C., Gustafsson, L., Cebere, A., Nylander, I., Liljequist, S. Brain Res. (2006) [Pubmed]
  5. Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS. Donner, M.G., Warskulat, U., Saha, N., Häussinger, D. Biol. Chem. (2004) [Pubmed]
  6. The role of microvascular permeability in the mechanism for stunned myocardium in rats. Chen, J.M., Gong, X.Q., Zhong, J.G., Chen, S.C., Zhang, G.Y., Wu, Z.G., Yang, Y.J. Microvasc. Res. (1997) [Pubmed]
  7. Effects of maternal separation on voluntary ethanol intake and brain peptide systems in female Wistar rats. Gustafsson, L., Ploj, K., Nylander, I. Pharmacol. Biochem. Behav. (2005) [Pubmed]
  8. Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones. Hirrlinger, J., König, J., Dringen, R. J. Neurochem. (2002) [Pubmed]
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