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Gene Review

GLRA2  -  glycine receptor, alpha 2

Homo sapiens

Synonyms: Glycine receptor subunit alpha-2
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Psychiatry related information on GLRA2

  • Based on its established expression pattern and known function, GLRA2 was selected as a candidate gene for Rett syndrome [1].

High impact information on GLRA2

  • YACs were isolated initially from four libraries either by hybridization or using sequence tagged sites (STSs) for DXS16, DXS9, GLRA2, DXS207, DXS43, DXS1416, DXS1317, DXS1195, and DXS418 [2].
  • The gene that encodes the human alpha2 subunit of the inhibitory glycine receptor (GLRA2) is located on the X chromosome (Xp22.2) in a candidate region for a number of neurological disorders [1].
  • To identify more subtle mutations, we determined the genomic structure for GLRA2, which consists of nine exons and a putative alternatively spliced exon 3 [1].
  • Major gene rearrangements were excluded based on Southern analysis using the GLRA2 cDNA as probe [1].
  • The complete coding sequence and splice junctions of the GLRA2 gene were scanned by DOVAM-S, a form of SSCP analysis with sufficient redundancy to detect virtually all mutations [3].


  1. Analysis of the genomic structure of the human glycine receptor alpha2 subunit gene and exclusion of this gene as a candidate for Rett syndrome. Cummings, C.J., Dahle, E.J., Zoghbi, H.Y. Am. J. Med. Genet. (1998) [Pubmed]
  2. A 6-Mb YAC contig in Xp22.1-p22.2 spanning the DXS69E, XE59, GLRA2, PIGA, GRPR, CALB3, and PHKA2 genes. Alitalo, T., Francis, F., Kere, J., Lehrach, H., Schlessinger, D., Willard, H.F. Genomics (1995) [Pubmed]
  3. Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases. Feng, J., Craddock, N., Jones, I.R., Cook, E.H., Goldman, D., Heston, L.L., Peltonen, L., DeLisi, L.E., Sommer, S.S. Psychiatr. Genet. (2001) [Pubmed]
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