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Gene Review

GNB2  -  guanine nucleotide binding protein (G...

Homo sapiens

Synonyms: G protein subunit beta-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, Transducin beta chain 2
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High impact information on GNB2


Biological context of GNB2


Other interactions of GNB2

  • Whereas 3 genes (GNB2, EPO, PCOLCE) were known previously on the mRNA level, we have been able to identify 10 novel genes using a newly developed automatic annotation tool RUMMAGE-DP, which comprises >26 different programs mainly for exon prediction, homology searches, and compositional and repeat analysis [6].


  1. Direct selection: a method for the isolation of cDNAs encoded by large genomic regions. Lovett, M., Kere, J., Hinton, L.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Blatt, C., Eversole-Cire, P., Cohn, V.H., Zollman, S., Fournier, R.E., Mohandas, L.T., Nesbitt, M., Lugo, T., Jones, D.T., Reed, R.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. G protein beta2 subunit-derived peptides for inhibition and induction of G protein pathways. Examination of voltage-gated Ca2+ and G protein inwardly rectifying K+ channels. Li, X., Hümmer, A., Han, J., Xie, M., Melnik-Martinez, K., Moreno, R.L., Buck, M., Mark, M.D., Herlitze, S. J. Biol. Chem. (2005) [Pubmed]
  4. Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit. Waragai, M., Nagamitsu, S., Xu, W., Li, Y.J., Lin, X., Ashizawa, T. J. Neurosci. Res. (2006) [Pubmed]
  5. G protein beta2 subunit antisense oligonucleotides inhibit cell proliferation and disorganize microtubule and mitotic spindle organization. Wu, H.C., Huang, P.H., Chiu, C.Y., Lin, C.T. J. Cell. Biochem. (2001) [Pubmed]
  6. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. Glöckner, G., Scherer, S., Schattevoy, R., Boright, A., Weber, J., Tsui, L.C., Rosenthal, A. Genome Res. (1998) [Pubmed]
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