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C4A  -  complement component 4A

Bos taurus

 
 
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High impact information on C4A

  • The insert DNAs containing the P-450(C21) genes were also hybridized with the sequences of the 5' or 3' end regions of human C4 cDNA, indicating a close linkage of the P-450(C21) gene to the C4 gene [1].
  • It seemed likely that this haplotype carries a deletion encompassing the genes encoding both C4A and 21-OHase [2].
  • Subsequent mutagenesis of the C4-loop revealed the role of Phe313 and Met317 [3].
  • Three cytoplasmic loops in the G protein-coupled receptor rhodopsin, C2, C3, and C4, have been implicated as key sites for binding and activation of the visual G protein transducin [3].
  • The C4 template mutant was unable to bind 11-cis-retinal, and the presence of Asn310/Lys311 was required for correct folding of the protein [3].
 

Biological context of C4A

  • Comparison of the nucleotide sequences of the isotype-determining region of the sheep and cattle C4 genes with those of the primates and mouse suggests that the C4A-like genes evolved independently in the primates and the ungulates [4].
  • EcoRI and BamHI RFLP polymorphism of bovine complement C4 gene [5].
 

Associations of C4A with chemical compounds

  • The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OHase deficiency and always carries a null allele at the locus encoding the C4A (Rodgers) form of the fourth component (C4) of complement [2].
  • Mutant opsins with residues 140-148 (C2-loop), 229-244 (C3-loop), or 310-320 (C4-loop) substituted by poly-Ala sequences of equivalent lengths served as templates for mutagenesis [3].

References

  1. Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene. Higashi, Y., Yoshioka, H., Yamane, M., Gotoh, O., Fujii-Kuriyama, Y. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation. White, P.C., New, M.I., Dupont, B. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Rhodopsin determinants for transducin activation: a gain-of-function approach. Natochin, M., Gasimov, K.G., Moussaif, M., Artemyev, N.O. J. Biol. Chem. (2003) [Pubmed]
  4. The thioester and isotypic sites of complement component C4 in sheep and cattle. Ren, X.D., Dodds, A.W., Law, S.K. Immunogenetics (1993) [Pubmed]
  5. EcoRI and BamHI RFLP polymorphism of bovine complement C4 gene. Groth, D.M., Lintorn-Terry, E., Taylor, L., Carrick, M., Wetherall, J.D. Nucleic Acids Res. (1990) [Pubmed]
 
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