Gene Review:
C4B - complement component 4B (Chido blood group)
Homo sapiens
Synonyms:
C4B1, C4B12, C4B2, C4B3, C4B5, ...
- Determining the one, two, three, or four long and short loci of human complement C4 in a major histocompatibility complex haplotype encoding C4A or C4B proteins. Chung, E.K., Yang, Y., Rupert, K.L., Jones, K.N., Rennebohm, R.M., Blanchong, C.A., Yu, C.Y. Am. J. Hum. Genet. (2002)
- Amino acid residues 1101-1105 of the isotypic region of human C4B is important to the covalent binding activity of complement component C4. Reilly, B.D., Levine, R.P., Skanes, V.M. J. Immunol. (1991)
- Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis. Nakagawa, H., Akazaki, S., Asahina, A., Tokunaga, K., Matsuki, K., Kuwata, S., Ishibashi, Y., Juji, T. Arch. Dermatol. Res. (1991)
- Polymorphism of the human complement C4 and steroid 21-hydroxylase genes. Restriction fragment length polymorphisms revealing structural deletions, homoduplications, and size variants. Schneider, P.M., Carroll, M.C., Alper, C.A., Rittner, C., Whitehead, A.S., Yunis, E.J., Colten, H.R. J. Clin. Invest. (1986)
- Individuals with IgA deficiency and common variable immunodeficiency share polymorphisms of major histocompatibility complex class III genes. Schaffer, F.M., Palermos, J., Zhu, Z.B., Barger, B.O., Cooper, M.D., Volanakis, J.E. Proc. Natl. Acad. Sci. U.S.A. (1989)
- HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type. Nerl, C., Mayeux, R., O'Neill, G.J. Neurology (1984)
- Immunogenetic studies in autism and related disorders. Warren, R.P., Singh, V.K., Averett, R.E., Odell, J.D., Maciulis, A., Burger, R.A., Daniels, W.W., Warren, W.L. Mol. Chem. Neuropathol. (1996)
- Complement C4 phenotypes in dementia of the Alzheimer type. Eikelenboom, P., Goetz, J., Pronk, J.C., Hauptmann, G. Hum. Hered. (1988)
- A class switch control region at the 3' end of the immunoglobulin heavy chain locus. Cogné, M., Lansford, R., Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H.L., Alt, F.W. Cell (1994)
- CH gene rearrangements in IgM-bearing B cells and in the normal splenic DNA component of hybridomas making different isotypes of antibody. Hurwitz, J.L., Coleclough, C., Cebra, J.J. Cell (1980)
- The reaction mechanism of the internal thioester in the human complement component C4. Dodds, A.W., Ren, X.D., Willis, A.C., Law, S.K. Nature (1996)
- Major histocompatibility complex markers in patients with nomifensine-induced immune hemolytic anemia. Mueller-Eckhardt, G., Giers, G., Salama, A., Schendel, D.J., Fass, G., Mueller-Eckhardt, C. Vox Sang. (1988)
- High-level expression of a recombinant fragment of human fibronectin containing the Cell I-Hep II-IIICS71 domain in Escherichia coli as a soluble protein. Li, M., Feng, Z., Zhang, G., Li, D. Biotechnol. Lett. (2006)
- Genetic sophistication of human complement components C4A and C4B and RP-C4-CYP21-TNX (RCCX) modules in the major histocompatibility complex. Chung, E.K., Yang, Y., Rennebohm, R.M., Lokki, M.L., Higgins, G.C., Jones, K.N., Zhou, B., Blanchong, C.A., Yu, C.Y. Am. J. Hum. Genet. (2002)
- Defective, deleted or converted CYP21B gene and negative association with a rare restriction fragment length polymorphism allele of the factor B gene in congenital adrenal hyperplasia. Ghanem, N., Lobaccaro, J.M., Buresi, C., Abbal, M., Halaby, G., Sultan, C., Lefranc, G. Hum. Genet. (1990)
- CYP21B gene conversion and complete CYP21A gene deletion in congenital adrenal hyperplasia. Lobaccaro, J.M., Ghanem, N., Lefranc, G., Sultan, C. Ann. Genet. (1990)
- Complement-dependent binding of C-reactive protein complexes to human erythrocyte CR1. Mold, C., Gurulé, C., Otero, D., Du Clos, T.W. Clin. Immunol. Immunopathol. (1996)
- Unequal expression of complement C4A and C4B genes in rheumatoid synovial cells, human monocytoid and hepatoma-derived cell lines. Falus, A., Kramer, J., Walcz, E., Varga, Z., Setalo, J., Jobst, K., Lakatos, T., Merétey, K. Immunology (1989)
- Synthesis and regulation of the two human complement C4 genes in stable transfected mouse fibroblasts. Miura, N., Prentice, H.L., Schneider, P.M., Perlmutter, D.H. J. Biol. Chem. (1987)
- Is decreased blood plasma concentration of the complement C4B protein associated with attention-deficit hyperactivity disorder? Warren, R.P., Odell, J.D., Warren, W.L., Burger, R.A., Maciulis, A., Torres, A.R. Journal of the American Academy of Child and Adolescent Psychiatry. (1995)
- Defective prevention of immune precipitation in autoimmune diseases is independent of C4A*Q0. Arason, G.J., Kolka, R., Hreidarsson, A.B., Gudjonsson, H., Schneider, P.M., Fry, L., Arnason, A. Clin. Exp. Immunol. (2005)
- Hemolytically inactive C4B complement allotype caused by a proline to leucine mutation in the C5-binding site. McLean, R.H., Niblack, G., Julian, B., Wang, T., Wyatt, R., Phillips, J.A., Collins, T.S., Winkelstein, J., Valle, D. J. Biol. Chem. (1994)
- A single arginine to tryptophan interchange at beta-chain residue 458 of human complement component C4 accounts for the defect in classical pathway C5 convertase activity of allotype C4A6. Implications for the location of a C5 binding site in C4. Ebanks, R.O., Jaikaran, A.S., Carroll, M.C., Anderson, M.J., Campbell, R.D., Isenman, D.E. J. Immunol. (1992)
- Serum concentrations of C4 isotypes and factor B in type I C2 deficiency suggest haplotype-dependent quantitative expression of MHC class III complement genes. Truedsson, L., Gullstrand, B., Jönsson, T., Klint, C. Exp. Clin. Immunogenet. (1995)
- Binding to erythrocyte complement receptor type 1 of BSA/anti-BSA complexes opsonized by C4A3 or C4B1 in the presence of serum. Klint, C., Truedsson, L., Sturfelt, G. Scand. J. Immunol. (1995)
- C4-mediated inhibition of immune precipitation and differences in inhibitory action of genetic variants, C4A3 and C4B1. Paul, L., Skanes, V.M., Mayden, J., Levine, R.P. Complement (1988)
- Characterization of a de novo conversion in human complement C4 gene producing a C4B5-like protein. Jaatinen, T., Eholuoto, M., Laitinen, T., Lokki, M.L. J. Immunol. (2002)
- Are major histocompatibility system class III products independent markers for susceptibility to rheumatoid arthritis? Dyer, P.A., Thomson, W., Sanders, P.A., Grennan, D.M. Dis. Markers (1986)
- Two HLA-linked loci controlling the fourth component of human complement. O'Neill, G.J., Yang, S.Y., Dupont, B. Proc. Natl. Acad. Sci. U.S.A. (1978)
- Inhibition of the intrinsic factor X activating complex by protein S: evidence for a specific binding of protein S to factor VIII. Koppelman, S.J., Hackeng, T.M., Sixma, J.J., Bouma, B.N. Blood (1995)
- DNA sequence analysis of the C4 antigen WH: evidence for two mechanisms of expression. Moulds, J.M., Roberts, S.L., Wells, T.D. Immunogenetics (1996)
- Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s. Reilly, B.D. Mol. Immunol. (2006)