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TPPP  -  tubulin polymerization promoting protein

Bos taurus

 
 
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Disease relevance of TPPP

  • Previously, we have demonstrated the presence of a protein factor [tubulin polymerization perturbing protein (TPPP)] in brain and neuroblastoma cell but not in muscle extract that uniquely influences the microtubule assembly [1].
 

High impact information on TPPP

  • The Km for UDP-N-acetylgalactosamine was 110 microM and that for an octapeptide acceptor (VTPRTPPP) was 3.0 mM at 37 degrees C. Using a range of synthetic peptides of known structure related to TPPP it was established that L-threonine residues were specifically O-glycosylated probably in the alpha-configuration [2].
  • In transfected HeLa cells at low expression level of EGFP-TPPP/p25, while the green fusion protein aligned at the microtubular network, GAPDH distributed uniformly in the cytosol [3].
  • TPPP/p25, a flexible unstructured protein, binds to tubulin and induces aberrant microtubule assemblies [3].
  • Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies [3].

References

  1. Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. Hlavanda, E., Kovács, J., Oláh, J., Orosz, F., Medzihradszky, K.F., Ovádi, J. Biochemistry (2002) [Pubmed]
  2. Polypeptide N-acetylgalactosaminyltransferase activity in tracheal epithelial microsomes. Cottrell, J.M., Hall, R.L., Sturton, R.G., Kent, P.W. Biochem. J. (1992) [Pubmed]
  3. Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. Ol??h, J., Tok??si, N., Vincze, O., Horv??th, I., Lehotzky, A., Erdei, A., Sz??jli, E., Medzihradszky, K.F., Orosz, F., Kov??cs, G.G., Ov??di, J. FEBS Lett. (2006) [Pubmed]
 
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