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MeSH Review

Lewy Bodies

 
 
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Disease relevance of Lewy Bodies

 

Psychiatry related information on Lewy Bodies

 

High impact information on Lewy Bodies

 

Chemical compound and disease context of Lewy Bodies

 

Biological context of Lewy Bodies

 

Anatomical context of Lewy Bodies

 

Associations of Lewy Bodies with chemical compounds

 

Gene context of Lewy Bodies

  • Our results indicate that ubiquilin may be an important modulator of presenilin protein accumulation and that ubiquilin protein is associated with neuropathological neurofibrillary tangles and Lewy body inclusions in diseased brain [33].
  • Further evidence that SIAH proteins may play a role in inclusion formation comes from the demonstration of SIAH immunoreactivity in Lewy bodies of PD patients [27].
  • We considered that the mutant PSEN1 might play an important role in the pathogenetic process of both aggregation of alpha-synuclein into Lewy bodies and deposition of beta-amyloid into cotton wool plaques [34].
  • The results of the Sagamihara family, in combination with the unique pathological features characterized by pure nigral degeneration without Lewy bodies, provided us with valuable information for elucidating the protein structure-pathogenesis relationship for the gene product of LRRK2 [35].
  • Many PNMT-positive neurons contained Lewy bodies [36].
 

Analytical, diagnostic and therapeutic context of Lewy Bodies

References

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  26. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Spillantini, M.G., Crowther, R.A., Jakes, R., Hasegawa, M., Goedert, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Liani, E., Eyal, A., Avraham, E., Shemer, R., Szargel, R., Berg, D., Bornemann, A., Riess, O., Ross, C.A., Rott, R., Engelender, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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  34. A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease. Ishikawa, A., Piao, Y.S., Miyashita, A., Kuwano, R., Onodera, O., Ohtake, H., Suzuki, M., Nishizawa, M., Takahashi, H. Ann. Neurol. (2005) [Pubmed]
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