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MeSH Review

Lewy Bodies

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Disease relevance of Lewy Bodies


Psychiatry related information on Lewy Bodies


High impact information on Lewy Bodies


Chemical compound and disease context of Lewy Bodies


Biological context of Lewy Bodies


Anatomical context of Lewy Bodies


Associations of Lewy Bodies with chemical compounds


Gene context of Lewy Bodies

  • Our results indicate that ubiquilin may be an important modulator of presenilin protein accumulation and that ubiquilin protein is associated with neuropathological neurofibrillary tangles and Lewy body inclusions in diseased brain [33].
  • Further evidence that SIAH proteins may play a role in inclusion formation comes from the demonstration of SIAH immunoreactivity in Lewy bodies of PD patients [27].
  • We considered that the mutant PSEN1 might play an important role in the pathogenetic process of both aggregation of alpha-synuclein into Lewy bodies and deposition of beta-amyloid into cotton wool plaques [34].
  • The results of the Sagamihara family, in combination with the unique pathological features characterized by pure nigral degeneration without Lewy bodies, provided us with valuable information for elucidating the protein structure-pathogenesis relationship for the gene product of LRRK2 [35].
  • Many PNMT-positive neurons contained Lewy bodies [36].

Analytical, diagnostic and therapeutic context of Lewy Bodies


  1. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Chung, K.K., Zhang, Y., Lim, K.L., Tanaka, Y., Huang, H., Gao, J., Ross, C.A., Dawson, V.L., Dawson, T.M. Nat. Med. (2001) [Pubmed]
  2. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Lippa, C.F., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q. Ann. Neurol. (1999) [Pubmed]
  3. Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers. Pramstaller, P.P., Schlossmacher, M.G., Jacques, T.S., Scaravilli, F., Eskelson, C., Pepivani, I., Hedrich, K., Adel, S., Gonzales-McNeal, M., Hilker, R., Kramer, P.L., Klein, C. Ann. Neurol. (2005) [Pubmed]
  4. Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Hishikawa, N., Niwa, J., Doyu, M., Ito, T., Ishigaki, S., Hashizume, Y., Sobue, G. Am. J. Pathol. (2003) [Pubmed]
  5. alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. Hashimoto, M., Hsu, L.J., Rockenstein, E., Takenouchi, T., Mallory, M., Masliah, E. J. Biol. Chem. (2002) [Pubmed]
  6. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Lee, V.M., Giasson, B.I., Trojanowski, J.Q. Trends Neurosci. (2004) [Pubmed]
  7. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. McKeith, I., Del Ser, T., Spano, P., Emre, M., Wesnes, K., Anand, R., Cicin-Sain, A., Ferrara, R., Spiegel, R. Lancet (2000) [Pubmed]
  8. VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration. Hirabayashi, M., Inoue, K., Tanaka, K., Nakadate, K., Ohsawa, Y., Kamei, Y., Popiel, A.H., Sinohara, A., Iwamatsu, A., Kimura, Y., Uchiyama, Y., Hori, S., Kakizuka, A. Cell Death Differ. (2001) [Pubmed]
  9. Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus. Court, J., Spurden, D., Lloyd, S., McKeith, I., Ballard, C., Cairns, N., Kerwin, R., Perry, R., Perry, E. J. Neurochem. (1999) [Pubmed]
  10. Coexistence of Pick bodies and atypical Lewy bodies in the locus ceruleus neurons of Pick's disease. Takauchi, S., Yamauchi, S., Morimura, Y., Ohara, K., Morita, Y., Hayashi, S., Miyoshi, K. Acta Neuropathol. (1995) [Pubmed]
  11. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Engelender, S., Kaminsky, Z., Guo, X., Sharp, A.H., Amaravi, R.K., Kleiderlein, J.J., Margolis, R.L., Troncoso, J.C., Lanahan, A.A., Worley, P.F., Dawson, V.L., Dawson, T.M., Ross, C.A. Nat. Genet. (1999) [Pubmed]
  12. In-vivo demonstration of dopaminergic degeneration in dementia with Lewy bodies. Walker, Z., Costa, D.C., Ince, P., McKeith, I.G., Katona, C.L. Lancet (1999) [Pubmed]
  13. Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene. Rempfer, R., Crook, R., Houlden, H., Duff, K., Hutton, M., Roberts, G.W., Raghavan, R., Perry, R., Hardy, J. Lancet (1994) [Pubmed]
  14. Tacrine for senile dementia of Alzheimer's or Lewy body type. Wilcock, G.K., Scott, M.I. Lancet (1994) [Pubmed]
  15. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Lo Bianco, C., Schneider, B.L., Bauer, M., Sajadi, A., Brice, A., Iwatsubo, T., Aebischer, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  16. Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease. Hashimoto, M., Bar-On, P., Ho, G., Takenouchi, T., Rockenstein, E., Crews, L., Masliah, E. J. Biol. Chem. (2004) [Pubmed]
  17. Alzheimer's disease and its Lewy body variant: a clinical analysis of postmortem verified cases. Weiner, M.F., Risser, R.C., Cullum, C.M., Honig, L., White, C., Speciale, S., Rosenberg, R.N. The American journal of psychiatry. (1996) [Pubmed]
  18. Dementia with Lewy bodies: response of delirium-like features to donepezil. Kaufer, D.I., Catt, K.E., Lopez, O.L., DeKosky, S.T. Neurology (1998) [Pubmed]
  19. Contribution of neuroimaging in the diagnosis of Alzheimer's disease and other dementias. Scheltens, P., Korf, E.S. Curr. Opin. Neurol. (2000) [Pubmed]
  20. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Conway, K.A., Harper, J.D., Lansbury, P.T. Nat. Med. (1998) [Pubmed]
  21. Genetics of Parkinson's disease. Nussbaum, R.L., Polymeropoulos, M.H. Hum. Mol. Genet. (1997) [Pubmed]
  22. Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease. Harrington, C.R., Louwagie, J., Rossau, R., Vanmechelen, E., Perry, R.H., Perry, E.K., Xuereb, J.H., Roth, M., Wischik, C.M. Am. J. Pathol. (1994) [Pubmed]
  23. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. Imai, Y., Soda, M., Murakami, T., Shoji, M., Abe, K., Takahashi, R. J. Biol. Chem. (2003) [Pubmed]
  24. Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5. Brion, J.P., Couck, A.M. Am. J. Pathol. (1995) [Pubmed]
  25. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. Wilson, C.A., Murphy, D.D., Giasson, B.I., Zhang, B., Trojanowski, J.Q., Lee, V.M. J. Cell Biol. (2004) [Pubmed]
  26. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Spillantini, M.G., Crowther, R.A., Jakes, R., Hasegawa, M., Goedert, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Liani, E., Eyal, A., Avraham, E., Shemer, R., Szargel, R., Berg, D., Bornemann, A., Riess, O., Ross, C.A., Rott, R., Engelender, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  28. Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival. Muqit, M.M., Davidson, S.M., Payne Smith, M.D., MacCormac, L.P., Kahns, S., Jensen, P.H., Wood, N.W., Latchman, D.S. Hum. Mol. Genet. (2004) [Pubmed]
  29. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Dexter, D.T., Sian, J., Rose, S., Hindmarsh, J.G., Mann, V.M., Cooper, J.M., Wells, F.R., Daniel, S.E., Lees, A.J., Schapira, A.H. Ann. Neurol. (1994) [Pubmed]
  30. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Iwata, A., Maruyama, M., Akagi, T., Hashikawa, T., Kanazawa, I., Tsuji, S., Nukina, N. Hum. Mol. Genet. (2003) [Pubmed]
  31. Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments. Jensen, P.H., Islam, K., Kenney, J., Nielsen, M.S., Power, J., Gai, W.P. J. Biol. Chem. (2000) [Pubmed]
  32. Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease. Fernandez, A., de Ceballos, M.L., Rose, S., Jenner, P., Marsden, C.D. Brain (1996) [Pubmed]
  33. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. Mah, A.L., Perry, G., Smith, M.A., Monteiro, M.J. J. Cell Biol. (2000) [Pubmed]
  34. A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease. Ishikawa, A., Piao, Y.S., Miyashita, A., Kuwano, R., Onodera, O., Ohtake, H., Suzuki, M., Nishizawa, M., Takahashi, H. Ann. Neurol. (2005) [Pubmed]
  35. An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family. Funayama, M., Hasegawa, K., Ohta, E., Kawashima, N., Komiyama, M., Kowa, H., Tsuji, S., Obata, F. Ann. Neurol. (2005) [Pubmed]
  36. Loss of C1 and C3 epinephrine-synthesizing neurons in the medulla oblongata in Parkinson's disease. Gai, W.P., Geffen, L.B., Denoroy, L., Blessing, W.W. Ann. Neurol. (1993) [Pubmed]
  37. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. Uryu, K., Richter-Landsberg, C., Welch, W., Sun, E., Goldbaum, O., Norris, E.H., Pham, C.T., Yazawa, I., Hilburger, K., Micsenyi, M., Giasson, B.I., Bonini, N.M., Lee, V.M., Trojanowski, J.Q. Am. J. Pathol. (2006) [Pubmed]
  38. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Hashimoto, M., Rockenstein, E., Mante, M., Crews, L., Bar-On, P., Gage, F.H., Marr, R., Masliah, E. Gene Ther. (2004) [Pubmed]
  39. Presenile dementia with Lewy bodies and neurofibrillary tangles. Forno, L.S., Barbour, P.J., Norville, R.L. Arch. Neurol. (1978) [Pubmed]
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