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Gene Review

TPPP  -  tubulin polymerization promoting protein

Homo sapiens

Synonyms: 25 kDa brain-specific protein, TPPP/p25, TPPP1, Tubulin polymerization-promoting protein, p24, ...
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Disease relevance of TPPP


Psychiatry related information on TPPP


High impact information on TPPP

  • These studies suggest that platelet activation mediated by the surface protein p24/CD9 is mainly through the stimulation of a phospholipase C, the activation of which is responsible for the generation of second messengers inositol trisphosphate and DAG [5].
  • We show that at low expression levels EGFP-TPPP/p25 specifically colocalizes with the microtubule network of HeLa and NRK cells [6].
  • Time-lapse and immunofluorescence experiments revealed that high levels of EGFP-TPPP/p25 inhibited cell division and promoted cell death [6].
  • We propose that a potential function of TPPP/p25 is the stabilization of physiological microtubular ultrastructures, however, its upregulation may directly or indirectly initiate the formation of aberrant protein aggregates such as pathological inclusions [6].
  • Having localized its expression to neuronal tissue by Western blot analyses, the distribution of p25alpha/TPPP to developing oligodendrocytes was confirmed using a specific antibody [7].

Biological context of TPPP


Anatomical context of TPPP


Associations of TPPP with chemical compounds

  • Our modelling using these data and rate equations of the individual enzymes suggests that the TPPP/p25 expression stimulates glucose metabolism [3].
  • Generation, characterization and cross-reactivities of monoclonal antibodies against the p24 core protein and the gp130 envelope glycoprotein of HIV-2ben [12].

Regulatory relationships of TPPP

  • The combination of our in vitro and in vivo data suggests that ERK2 can regulate TPPP activity via the phosphorylation of Thr(14) and/or Ser(18) in its unfolded N-terminal tail [13].

Co-localisations of TPPP

  • However, at high expression level, GAPDH co-localized with TPPP/p25 in the aggresome-like aggregate [11].

Other interactions of TPPP


Analytical, diagnostic and therapeutic context of TPPP

  • There is a correlation between TPPP/p25 and alpha-synuclein immunoreactivity in Western blot [1].
  • The previous and the present studies obtained with immunohistochemistry with pathological human brain tissues rendered it possible to classify among pathological inclusions on the basis of immunolabelling of TPPP/p25, and suggest this protein to be a potential linkage between Parkinson's and Alzheimer's diseases [3].
  • Evaluation of a new fourth generation enzyme-linked immunosorbent assay, the LG HIV Ag-Ab Plus, with a combined HIV p24 antigen and anti-HIV-1/2/O screening test [14].


  1. Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Kovács, G.G., László, L., Kovács, J., Jensen, P.H., Lindersson, E., Botond, G., Molnár, T., Perczel, A., Hudecz, F., Mezo, G., Erdei, A., Tirián, L., Lehotzky, A., Gelpi, E., Budka, H., Ovádi, J. Neurobiol. Dis. (2004) [Pubmed]
  2. The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases. Kovács, G.G., Gelpi, E., Lehotzky, A., Höftberger, R., Erdei, A., Budka, H., Ovádi, J. Acta Neuropathol. (2007) [Pubmed]
  3. TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments. Orosz, F., Kovács, G.G., Lehotzky, A., Oláh, J., Vincze, O., Ovádi, J. Biol. Cell (2004) [Pubmed]
  4. Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector. Frankel, F.R., Hegde, S., Lieberman, J., Paterson, Y. J. Immunol. (1995) [Pubmed]
  5. The activation of human platelets mediated by anti-human platelet p24/CD9 monoclonal antibodies. Jennings, L.K., Fox, C.F., Kouns, W.C., McKay, C.P., Ballou, L.R., Schultz, H.E. J. Biol. Chem. (1990) [Pubmed]
  6. Dynamic targeting of microtubules by TPPP/p25 affects cell survival. Lehotzky, A., Tirián, L., Tökési, N., Lénárt, P., Szabó, B., Kovács, J., Ovádi, J. J. Cell. Sci. (2004) [Pubmed]
  7. P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain. Skjoerringe, T., Lundvig, D.M., Jensen, P.H., Moos, T. J. Neurochem. (2006) [Pubmed]
  8. A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3. Seki, N., Hattori, A., Sugano, S., Suzuki, Y., Nakagawara, A., Muramatsu, M., Hori, T., Saito, T. J. Hum. Genet. (1999) [Pubmed]
  9. P24, a glycogen synthase kinase 3 (GSK 3) inhibitor. Martín, C.P., Vázquez, J., Avila, J., Moreno, F.J. Biochim. Biophys. Acta (2002) [Pubmed]
  10. Evidence for a 3p25 breakpoint hot spot region in thyroid tumors of follicular origin. Drieschner, N., Belge, G., Rippe, V., Meiboom, M., Loeschke, S., Bullerdiek, J. Thyroid (2006) [Pubmed]
  11. Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. Ol??h, J., Tok??si, N., Vincze, O., Horv??th, I., Lehotzky, A., Erdei, A., Sz??jli, E., Medzihradszky, K.F., Orosz, F., Kov??cs, G.G., Ov??di, J. FEBS Lett. (2006) [Pubmed]
  12. Generation, characterization and cross-reactivities of monoclonal antibodies against the p24 core protein and the gp130 envelope glycoprotein of HIV-2ben. Faisst, A.C., Otteken, A., Nick, S., Hunsmann, G. Med. Microbiol. Immunol. (Berl.) (1993) [Pubmed]
  13. Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. Hlavanda, E., Klement, E., Kókai, E., Kovács, J., Vincze, O., Tökési, N., Orosz, F., Medzihradszky, K.F., Dombrádi, V., Ovádi, J. J. Biol. Chem. (2007) [Pubmed]
  14. Evaluation of a new fourth generation enzyme-linked immunosorbent assay, the LG HIV Ag-Ab Plus, with a combined HIV p24 antigen and anti-HIV-1/2/O screening test. Yeom, J.S., Jun, G., Chang, Y., Sohn, M.J., Yoo, S., Kim, E., Ryu, S.H., Kang, H.J., Kim, Y.A., Ahn, S.Y., Cha, J.E., Youn, S.T., Park, J.W. J. Virol. Methods (2006) [Pubmed]
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