Gene Review:
CD28 - CD28 molecule
Bos taurus
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High impact information on CD28
- This pathway can be blocked by CTLA-4-Ig, a soluble form of CTLA-4 which binds with high avidity to the CD28 ligands, B7-1 and B7-2 [1].
- There is evidence from in vitro and in vivo experimental systems suggesting that the CD28/B7 costimulatory pathway is crucial for induction of maximal T cell proliferation and T helper-B cell collaboration for IgG production [1].
References
- Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. Knoerzer, D.B., Karr, R.W., Schwartz, B.D., Mengle-Gaw, L.J. J. Clin. Invest. (1995) [Pubmed]
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