High impact information on CD28

• Monomeric homologue of mammalian CD28 is expressed on chicken T cells [1].
• The sequence of the cDNA obtained encoded a molecule having 50% amino acid sequence identity with mammalian CD28, but the cysteine residue involved in the inter-chain bridge of the mammalian CD28 homodimer was not conserved in the chicken sequence [1].
• X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2 [2].
• BACKGROUND: The proto-oncogene product c-Rel is a Rel/NF-kappaB family transcription factor that plays a critical role in lymphoid cell development and mediates CD28-induced expression of interleukin 2 (IL-2) [2].
• The CD28 response element (CD28RE) in the IL-2 enhancer is nonameric and similar to the kappaB DNA target sites recognized by p65 homodimers [2].

Biological context of CD28

• TaqI and HaeIII RFLP at the locus encoding the chicken homologue of CD28 [3].

Associations of CD28 with chemical compounds

• These responses were resistant to cyclosporin A, but inhibited by herbimycin A, suggesting that CD28 employs a signalling pathway at least partly distinct from that triggered by TCR/CD3 [4].

Other interactions of CD28

• UA04 cells express CD3low, CD4, TCR-2low, MHC class II, and CD28 antigens on their surface [5].

Analytical, diagnostic and therapeutic context of CD28

• CD28 mRNA was examined by PCR [6].

References