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Gene Review

CD28  -  CD28 molecule

Gallus gallus

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High impact information on CD28


Biological context of CD28

  • TaqI and HaeIII RFLP at the locus encoding the chicken homologue of CD28 [3].

Associations of CD28 with chemical compounds

  • These responses were resistant to cyclosporin A, but inhibited by herbimycin A, suggesting that CD28 employs a signalling pathway at least partly distinct from that triggered by TCR/CD3 [4].

Other interactions of CD28

  • UA04 cells express CD3low, CD4, TCR-2low, MHC class II, and CD28 antigens on their surface [5].

Analytical, diagnostic and therapeutic context of CD28


  1. Monomeric homologue of mammalian CD28 is expressed on chicken T cells. Young, J.R., Davison, T.F., Tregaskes, C.A., Rennie, M.C., Vainio, O. J. Immunol. (1994) [Pubmed]
  2. X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2. Huang, D.B., Chen, Y.Q., Ruetsche, M., Phelps, C.B., Ghosh, G. Structure (Camb.) (2001) [Pubmed]
  3. TaqI and HaeIII RFLP at the locus encoding the chicken homologue of CD28. Bumstead, N., Young, J.R., Tregaskes, C. Anim. Genet. (1993) [Pubmed]
  4. Evolutionarily conserved function of CD28 in alpha beta T cell activation. Arstila, T.P., Vainio, O., Lassila, O. Scand. J. Immunol. (1994) [Pubmed]
  5. Establishment of a lymphoblastoid cell line using a mutant MDV containing a green fluorescent protein expression cassette. Dienglewicz, R.L., Parcells, M.S. Acta Virol. (1999) [Pubmed]
  6. Identification of the neoplastically transformed cells in Marek's disease herpesvirus-induced lymphomas: recognition by the monoclonal antibody AV37. Burgess, S.C., Davison, T.F. J. Virol. (2002) [Pubmed]
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