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Gene Review

CTLA4  -  cytotoxic T-lymphocyte-associated protein 4

Bos taurus

Synonyms: CD152, CTLA-4
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High impact information on CTLA4

  • This pathway can be blocked by CTLA-4-Ig, a soluble form of CTLA-4 which binds with high avidity to the CD28 ligands, B7-1 and B7-2 [1].
  • The expression of CD28 and CTLA-4 transcripts on bovine WC1+ T cells indicates that these genes are evolutionarily conserved [2].


  1. Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. Knoerzer, D.B., Karr, R.W., Schwartz, B.D., Mengle-Gaw, L.J. J. Clin. Invest. (1995) [Pubmed]
  2. Purification and characterisation of bovine WC1+ gammadelta T lymphocytes from peripheral blood. Fikri, Y., Nyabenda, J., Denis, M., Pastoret, P.P. Vet. Res. (2000) [Pubmed]
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