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Gene Review:

Cd28 - Cd28 molecule

Rattus norvegicus

Synonyms: T-cell-specific surface glycoprotein CD28

Nakatsuji, T., Reynolds, J. et al.

Nakatsuji, Reynolds, Tam, Chandraker, Smith, Karkar, Cross, Peach, Sayegh, Pusey,

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High impact information on Cd28

T-cell costimulation is provided by ligation of CD28 with either B7.1 (CD80) or B7.2 (CD86) on antigen-presenting cells, and can be inhibited by a soluble form of CTLA4 (CTLA4-Ig) that binds to both B7.1 and B7 [1].
Anti-CD2 MAb was effective for prolonging the liver graft survival with suppressed CD28 antigen, but anti-PDGFR-beta Ab and splenectomy were not [2].
In these 4 rats, CD28 antigen on thymic lymphocytes was down-modulated and high numbers (136-233-positive cells per lobe) of the epithelial reticular cells with apoptotic lymphocytes were counted [2].

References

CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. Reynolds, J., Tam, F.W., Chandraker, A., Smith, J., Karkar, A.M., Cross, J., Peach, R., Sayegh, M.H., Pusey, C.D. J. Clin. Invest. (2000) [Pubmed]
Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Nakatsuji, T. Tohoku J. Exp. Med. (1999) [Pubmed]

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