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Disease relevance of Blastocyst


Psychiatry related information on Blastocyst


High impact information on Blastocyst

  • In preimplantation embryos, Cdx2 is initially coexpressed with Oct3/4 and they form a complex for the reciprocal repression of their target genes in ES cells [9].
  • Nanog, a homeobox transcription factor, plays a crucial role in the second embryonic cell fate specification following formation of the blastocyst [10].
  • Here we show that null mutation of Trrap in mice results in peri-implantation lethality due to a blocked proliferation of blastocysts [11].
  • We disrupted the coding sequence of one allele of either Prm1 or Prm2 in embryonic stem (ES) cells derived from 129-strain mice, and injected them into blastocysts from C57BL/6-strain mice [12].
  • Oct4-deficient embryos develop to the blastocyst stage, but the inner cell mass cells are not pluripotent [13].

Chemical compound and disease context of Blastocyst


Biological context of Blastocyst


Anatomical context of Blastocyst


Associations of Blastocyst with chemical compounds


Gene context of Blastocyst

  • The earliest Xist expression in morulae and blastocysts is imprinted, resulting in specific expression of the paternal Xist allele [34].
  • In preimplantation embryos, Nanog is restricted to founder cells from which ES cells can be derived [35].
  • These results indicate a role for AbdB Hox genes in male and female fertility and suggest that maternal Hoxa10 is required to regulate the expression of a factor that affects the viability of preimplantation embryos [36].
  • Lymphocyte development and function was studied with the use of the RAG2-deficient blastocyst complementation system [37].
  • The closely linked H19 and Igf2 genes were activated after the blastocyst stage and often exhibited biallelic and monoallelic expression respectively in tissues of pregastrulation postimplantation-stage embryos, rather than reciprocal monoallelic modes as observed at later stages [38].

Analytical, diagnostic and therapeutic context of Blastocyst


  1. Reprogramming of a melanoma genome by nuclear transplantation. Hochedlinger, K., Blelloch, R., Brennan, C., Yamada, Y., Kim, M., Chin, L., Jaenisch, R. Genes Dev. (2004) [Pubmed]
  2. Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. Boller, K., Vestweber, D., Kemler, R. J. Cell Biol. (1985) [Pubmed]
  3. Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation. Paria, B.C., Elenius, K., Klagsbrun, M., Dey, S.K. Development (1999) [Pubmed]
  4. Participation of teratocarcinoma cells in mouse embryo development. Brinster, R.L. Cancer Res. (1976) [Pubmed]
  5. Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst. Chi, M.M., Pingsterhaus, J., Carayannopoulos, M., Moley, K.H. J. Biol. Chem. (2000) [Pubmed]
  6. Molecular evidence for a critical period in mural trophoblast development in bovine blastocysts. Degrelle, S.A., Campion, E., Cabau, C., Piumi, F., Reinaud, P., Richard, C., Renard, J.P., Hue, I. Dev. Biol. (2005) [Pubmed]
  7. Expression of urokinase-type plasminogen activator in human preimplantation embryos. Khamsi, F., Armstrong, D.T., Zhang, X. Mol. Hum. Reprod. (1996) [Pubmed]
  8. Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation. Kress, C., Vandormael-Pournin, S., Baldacci, P., Cohen-Tannoudji, M., Babinet, C. Mamm. Genome (1998) [Pubmed]
  9. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., Rossant, J. Cell (2005) [Pubmed]
  10. Nanog: a new recruit to the embryonic stem cell orchestra. Cavaleri, F., Schöler, H.R. Cell (2003) [Pubmed]
  11. Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Herceg, Z., Hulla, W., Gell, D., Cuenin, C., Lleonart, M., Jackson, S., Wang, Z.Q. Nat. Genet. (2001) [Pubmed]
  12. Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Cho, C., Willis, W.D., Goulding, E.H., Jung-Ha, H., Choi, Y.C., Hecht, N.B., Eddy, E.M. Nat. Genet. (2001) [Pubmed]
  13. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H., Smith, A. Cell (1998) [Pubmed]
  14. Unusual stage-specific embryonic antigen (TEC-4) defined by a monoclonal antibody to embryonal carcinoma cells defective in the expression of embryoglycan. Dráber, P., Nosek, J., Pokorná, Z. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  15. Carbohydrate structure and cell differentitation: unique properties of fucosyl-glycopeptides isolated from embryonal carcinoma cells. Muramatsu, T., Gachelin, G., Nicolas, J.F., Condamine, H., Jakob, H., Jacob, F. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  16. Accumulation of steroids in rabbit preimplantation blastocysts. Borland, R.M., Erickson, G.F., Ducibella, T. J. Reprod. Fertil. (1977) [Pubmed]
  17. Survival and development of bovine blastocysts produced in vitro after assisted hatching, vitrification and in-straw direct rehydration. Vajta, G., Holm, P., Greve, T., Callesen, H. J. Reprod. Fertil. (1997) [Pubmed]
  18. Transgenic mouse blastocysts that overexpress metallothionein-I resist cadmium toxicity in vitro. Lee, D.K., Fu, K., Liang, L., Dalton, T., Palmiter, R.D., Andrews, G.K. Mol. Reprod. Dev. (1996) [Pubmed]
  19. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Murphy, M., Stinnakre, M.G., Senamaud-Beaufort, C., Winston, N.J., Sweeney, C., Kubelka, M., Carrington, M., Bréchot, C., Sobczak-Thépot, J. Nat. Genet. (1997) [Pubmed]
  20. Temporally specific involvement of cell surface beta-1,4 galactosyltransferase during mouse embryo morula compaction. Bayna, E.M., Shaper, J.H., Shur, B.D. Cell (1988) [Pubmed]
  21. Estrogen formation in the early rabbit embryo. George, F.W., Wilson, J.D. Science (1978) [Pubmed]
  22. Does "blastocyst estrogen" initiate implantation? Dickmann, Z., Gupta, J.S., Dey, S.K. Science (1977) [Pubmed]
  23. Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Rappolee, D.A., Sturm, K.S., Behrendtsen, O., Schultz, G.A., Pedersen, R.A., Werb, Z. Genes Dev. (1992) [Pubmed]
  24. Development of activatable adenylate cyclase in the preimplantation mouse embryo and a role for cyclic AMP in blastocoel formation. Manejwala, F., Kaji, E., Schultz, R.M. Cell (1986) [Pubmed]
  25. Histamine receptors on rabbit blastocyst and endometrial cell membranes. Dey, S.K., Villanueva, C., Abdou, N.I. Nature (1979) [Pubmed]
  26. Molecular cues to implantation. Dey, S.K., Lim, H., Das, S.K., Reese, J., Paria, B.C., Daikoku, T., Wang, H. Endocr. Rev. (2004) [Pubmed]
  27. Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos. Rappolee, D.A., Brenner, C.A., Schultz, R., Mark, D., Werb, Z. Science (1988) [Pubmed]
  28. Monozygotic twin formation in mouse embryos in vitro. Hsu, Y.C., Gonda, M.A. Science (1980) [Pubmed]
  29. Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: compaction and trophoblast adhesion. Surani, M.A. Cell (1979) [Pubmed]
  30. Implication of absence of HCG-like gonadotrophin in the blastocyst for control of corpus luteum function in pregnant rabbit. Sundaram, K., Connell, K.G., Passantino, T. Nature (1975) [Pubmed]
  31. Inhibition of post-implantation development of mouse blastocysts in vitro after cyclophosphamide treatment in vivo. Eibs, H.G., Spielmann, H. Nature (1977) [Pubmed]
  32. Estrogen receptors in the nidatory sites of the rat endometrium. Martel, D., Psychoyos, A. Science (1981) [Pubmed]
  33. Local effect of the blastocyst on estrogen and progesterone receptors in the rat endometrium. Logeat, F., Sartor, P., Hai, M.T., Milgrom, E. Science (1980) [Pubmed]
  34. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation. Kay, G.F., Penny, G.D., Patel, D., Ashworth, A., Brockdorff, N., Rastan, S. Cell (1993) [Pubmed]
  35. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., Smith, A. Cell (2003) [Pubmed]
  36. Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Satokata, I., Benson, G., Maas, R. Nature (1995) [Pubmed]
  37. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Fruman, D.A., Snapper, S.B., Yballe, C.M., Davidson, L., Yu, J.Y., Alt, F.W., Cantley, L.C. Science (1999) [Pubmed]
  38. Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms. Szabó, P.E., Mann, J.R. Genes Dev. (1995) [Pubmed]
  39. Early mouse embryo intracisternal particle: Fourth type of retrovirus-like particle associated with the mouse. Yotsuyanagi, Y., Szöllösi, D. J. Natl. Cancer Inst. (1981) [Pubmed]
  40. Evidence for the involvement of the proto-oncogene c-mos in mammalian meiotic maturation and possibly very early embryogenesis. Mutter, G.L., Grills, G.S., Wolgemuth, D.J. EMBO J. (1988) [Pubmed]
  41. Steroidogenesis in rabbit preimplantation embryos. Dickmann, Z., Dey, S.K., Gupta, J.S. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  42. Blastocyst's state of activity determines the "window" of implantation in the receptive mouse uterus. Paria, B.C., Huet-Hudson, Y.M., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  43. Nucleolar distribution of proteins B23 and nucleolin in mouse preimplantation embryos as visualized by immunoelectron microscopy. Biggiogera, M., Bürki, K., Kaufmann, S.H., Shaper, J.H., Gas, N., Amalric, F., Fakan, S. Development (1990) [Pubmed]
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