Disease relevance of PKP1

• We have also found that, in all plakophilin 1-positive cells examined, a pool of diffusible ('soluble') cytoplasmic plakophilin exists, including cell lines such as human mammary carcinoma MCF-7 cells in which this soluble plakophilin seems to be the only detectable form [1].

High impact information on PKP1

• To characterize the structure of B6P in the desmosome we have isolated cDNA clones representing the entire coding sequence [2].
• These sequence characteristics define B6P as a novel member of the armadillo multigene family and raise the question of whether the structural proteins B6P, plakoglobin, beta-catenin and armadillo share some function [2].
• Thus B6P may play a role in ordering intermediate filament networks of adjacent epithelial cells [2].
• Significant differences were determined in the RA for Na/K, E-cad, Dc II, Plako, and ZO-1 transcripts between TE cells of expanded blastocysts derived from either Day 7 or Day 8 [3].
• Dc II and Dc III transcripts were found from 2-4-cell embryos up to the hatched blastocyst stage. mRNA encoding Plako was detected in immature and mature oocytes and zygotes, while no transcripts were seen in 2-4-cell and 8-16-cell embryos [4].

Biological context of PKP1

• Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family [2].
• Possible functions of plakophilin and its potential value as a marker for specific states of cell differentiation are discussed, particularly with respect to tumor diagnosis [1].

Anatomical context of PKP1

• Desmosomes can differ in their specific complement of desmogleins, Dsg1-3, and desmocollins, Dsc1a-3b, as well as in the additional presence and in their relative amounts of certain accessory plaque proteins such as desmoplakin II and plakophilin 1, a basic member of the larger plakoglobin family of proteins ("band 6 protein") [5].

Associations of PKP1 with chemical compounds

• Expression of glucose transporter 1 was significantly (P < 0.05) higher, and expression of desmocollin 2 and plakophilin tended to be higher (P < 0.1) for in vivo (group 4) compared with in vitro blastocysts (group 1), whereas no differences were found for heat shock protein 70.1, E-cadherin and poly(A) polymerase [6].

Analytical, diagnostic and therapeutic context of PKP1

• The plakophilin antibodies and cDNA probes have also allowed us to examine its synthesis in various tissues and cell cultures [1].

References