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Gene Review

FBN2  -  fibrillin 2

Bos taurus

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Disease relevance of FBN2


High impact information on FBN2

  • Using yeast two-hybrid, ligand blotting, and solid phase binding assays, we have shown that microfibril-associated glycoprotein-1 (MAGP-1) interacts with the 8-cysteine motif of fibrillin-2 encoded by exon 24 [1].
  • The matrix-binding domain, but not the full-length protein, also bound to regions of fibrillin-2 defined by exons 16 and 17, exon 20, and exons 23 and 24 [1].
  • The localization of MAGP-1 binding to the 8-Cys domain encoded by exon 24 suggests that the bead structure of microfibrils consists of exon 24 and portions of the central region of fibrillin-2 [1].
  • In fetal bovine nuchal ligament, mRNA levels for fibrillin-1 and fibrillin-2 increased approximately threefold during this period, whereas tropoelastin increased 20-fold [2].
  • Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues [2].

Biological context of FBN2


Anatomical context of FBN2


Other interactions of FBN2

  • Although the relative increase in expression of both fibrillins was equivalent, the basal level of fibrillin-1 expression was greater than fibrillin-2 [2].


  1. Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. Werneck, C.C., Trask, B.C., Broekelmann, T.J., Trask, T.M., Ritty, T.M., Segade, F., Mecham, R.P. J. Biol. Chem. (2004) [Pubmed]
  2. Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues. Mariencheck, M.C., Davis, E.C., Zhang, H., Ramirez, F., Rosenbloom, J., Gibson, M.A., Parks, W.C., Mecham, R.P. Connect. Tissue Res. (1995) [Pubmed]
  3. Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1. Sakamoto, H., Broekelmann, T., Cheresh, D.A., Ramirez, F., Rosenbloom, J., Mecham, R.P. J. Biol. Chem. (1996) [Pubmed]
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